Palmitoyl Tripeptide-8

Basic Information

Description

Physical Properties

• Appearance: White crystalline powder, odorless, with slight hygroscopicity .
• Solubility:
  • Soluble in water (≥5 mg/mL) and polar solvents (e.g., ethanol, DMSO) .
  • Insoluble in non-polar solvents (e.g., chloroform) .
• Stability:
  • pH Sensitivity: Stable at neutral pH (6.5–7.5) but hydrolyzes in acidic conditions .
  • Thermal Stability: Melts at 195–198°C and decomposes above 218°C .
  • Storage: Requires refrigeration (2–8°C) under dry nitrogen to prevent oxidation .

Chemical Structure

Key Data

• Purity:
  • Pharmaceutical Grade: ≥98% (HPLC) .
  • Cosmetic Grade: 98–99% .
• Optical Rotation:
  • \([\alpha]_D^{20} = -64.0° \pm 2.0°\) (3% aqueous solution) .
• UV Absorption: Maximum absorbance at 280 nm (peptide backbone) .
• Density: 1.20 ± 0.1 g/cm³ (predicted) .
• pKa: 13.34 ± 0.46 (predicted) .
• Melting Point: 195–198°C .

Functions

Core Biological Roles

1. Anti-Inflammatory Activity:
   • MC1-R Antagonism: Binds to MC1-R with high affinity, blocking α-melanocyte-stimulating hormone (α-MSH) and reducing IL-8, IL-1α, and TNF-α release in UV-damaged keratinocytes .
   • Neurogenic Edema Control: Reduces substance P-induced vasodilation and edema by 60% in skin explants .
2. Skin Barrier Protection:
   • Anti-Irritation: Mitigates UV-, mechanical-, and immune-induced skin irritation, restoring normal sensitivity thresholds .
   • Moisture Retention: Enhances ceramides and filaggrin synthesis, improving hydration and barrier function .
3. Anti-Aging Effects:
   • Collagen Stimulation: Activates TGF-β signaling in fibroblasts, increasing type I and III collagen production by 350% in vitro .
   • Elastin Support: Promotes elastin fiber organization, reducing fine lines and improving skin elasticity .
4. Sensitive Skin Management:
   • Redness & Itch Reduction: Alleviates erythema and pruritus by 30–50% in clinical trials .

Applications

Cosmetics & Skincare

• Anti-Aging: Reduces crow’s feet and deep wrinkles (e.g., Biologique Recherche Sérum Biosensible) .
• Sensitive Skin: Calms rosacea and post-procedural inflammation (e.g., SkinMedica Age Defense Retinol Complex) .
• UV Protection: Enhances sunscreen efficacy by reducing UV-induced inflammation .

Medical Aesthetics

• Post-Procedural Care: Accelerates recovery after laser resurfacing or chemical peels .
• Burn/Wound Healing: Promotes scar remodeling and tissue regeneration .

Research & Biotechnology

• Cell Culture: Enhances fibroblast viability and metabolic activity in vitro .
• Drug Delivery: Serves as a carrier for topical formulations (e.g., retinol, hyaluronic acid)