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6-Thioguanine 99% powder 154-42-7 Dideu

Name: 6-Thioguanine 99% powder 154-42-7 Dideu
Brand: Dideu
SKU: pr2211014418
Price: 1 USD
Availability: InStock

Unit Price:

$1/KG FOB

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CAS No.:

154-42-7

Grade:

Chemical Grade

Content:

99%

Port:

any port of China

Brand:

Dideu

Packaging:

Price valid (until):

2030-01-01

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Shaanxi Dideu Medichem Co. Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

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Product Description
Seller Information

Description

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Our Reference Specification, for more details, pls contact us for COA,MSDS and certification:
Email & Skype: 1055@dideu.com Telephone:+86-29-81136151
Mobile&Wechat&Whatsapp: +8617792984622

Items	Standard		Test Results
Identification	A.H-NMR:Comply with the structure		Complies
	B.LC-MS:Comply with the structure		Complies
	C.The IR spectrum of sample should be identical with that of reference standard.		Complies
	D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.		Complies
Loss on drying %	≤2.0		0.19
Heavy metals ppm	≤10		<10
Moisture %	≤1.0		0.1
Sulphated ash %	≤0.5 determined on 1.0 g.		0.009
Residue on ignition %	≤0.1		0.03
Related Substances %	Unspecified impurities: for each impurity	≤0.10	<0.10
Related Substances %	Total Impurity	≤0.5	0.18
Purity %	≥99.0		99.7
Assay %	99.0 ~101.0 (anhydrous substance).		99.8
Storage	Preserve in well-closed, light-resistant and airtight containers.		Complies

Our normal packaging is 25kgs/Drum，200kgs/Drum
The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

a) Free sample can be supplied.
b) Guide our clients by professional knowledge and teach them how to use our product after sales.
c) Accept SGS,BV any other third-party inspection before loading.
d) High quality best price Guaranteed.

Why do you choose Dideu Industries as your partner?

A) High quality can be guaranteed. Dideu Industries since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P,D/A payment term. If there is any quality problem after goods arrive. Dideu Industries will do fully payment refund.

B) Best price can be guaranteed. As Dideu Industries are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional enginners from Dideu Industries will give professional usage guide and services after sales.

D)Dideu Industries work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu Industries is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa.Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Group Dideu posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China,Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Industries Consist Of Five Industry Chains:

I)Pharmaceutical Industries
II)Nutrition Additive Industries
III)Daily-Use Chemical Products Industries & Agrochemicals
IV)Environmental Friendly Chemical And Chemurgy Industries
V)Petrochemical Industries
VI)General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility.Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life.Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials.We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms.Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu.Exclusive Focus on the Life Science BusinessesFollowing the economic and legal independence of our former Material Science subgroup.Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit.The business continues to be supported by the corporate functions, Dideu Business Services and the service company Currenta, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

product introduction information...

ECHEMI Editorial Reference

Crystalline, lyophilized, sterile, endotChEBI: A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine.The drug is available in 40-mg tablets for oral use.Thioguanine is used to treat acute nonlymphocytic leukemia.The mechanism of action involves incorporation of thetriphosphate into DNA and RNA, resulting in inhibition ofprocessing and function. Intracellular phosphorylation is requiredfor activity and inhibition of purine biosynthesis.Resistance can include decreased
6-thioguanine appears as odorless or almost odorless pale yellow crystalline powder. (NTP, 1992)|Solid
6-thioguanine appears as odorless or almost odorless pale yellow crystalline powder. (NTP, 1992)|Tioguanine is a 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. It has a role as an antineoplastic agent, an antimetabolite and an anticoronaviral agent.|An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.|Thioguanine anhydrous is an Antimetabolite.|Azathioprine is a purine analogue and prodrug of mercaptopurine that is used as an immunosuppressive agent in organ transplantation to prevent rejection and in autoimmune diseases as a corticosteroid sparing agent. Azathioprine is associated with minor, usually transient and asymptomatic elevations in serum aminotransferase levels during therapy and with rare instances of acute, cholestatic liver injury and, with long term use, noncirrhotic portal hypertension as a result of nodular regenerative hyperplasia or sinusoidal obstruction syndrome.|Thioguanine (also referred to as 6-thioguanine and as tioguanine) is a purine analogue that is used in the therapy of acute and chronic myelogenous leukemias. Thioguanine therapy is associated with minor, usually transient and asymptomatic elevations in serum aminotransferase levels and has also been linked to rare instances of cholestatic acute liver injury and to chronic liver injury, resulting in portal hypertension due to nodular regenerative hyperplasia.|Thioguanine Anhydrous is the anhydrous salt form of thioguanine, a synthetic guanosine analogue antimetabolite, with antineoplastic activity. Thioguanine is phosphorylated by hypoxanthine-guanine phosphoribosyltransferase to 6-thioguanylic acid (TGMP) and upon conversion to thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP), this agent is incorporated into DNA and RNA, resulting in inhibition of DNA and RNA synthesis and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine ribonulceotide synthesis.

Basic Info

Product Name:

Thioguanine

Other Name:

6H-Purine-6-thione,2-amino-1,9-dihydro-;6H-Purine-6-thione,2-amino-1,7-dihydro-;Purine-6(1H)-thione,2-amino-;Purine-6(1H)-thione,2,3-dihydro-2-imino-;Purine-6-thiol,2-amino-;2-Amino-1,9-dihydro-6H-purine-6-thione;NSC 752;Tabloid;6-Thioguanine;Guanine,thio-;Thioguanine;2-Amino-6-mercaptopurine;6-Mercaptoguanine;2-Aminopurine-6-thiol;Tioguanin;6-TG;Tioguanine;2-Amino-9H-purine-6(1H)-thione;NSC 76504;Lanvis;2-Amino-9H-purine-6-thiol;Thioguanine Tabloid;2-Amino-3,7-dihydropurine-6-thione;2-Amino-1H-purine-6(7H)-thione;2-Amino-1,9-dihydro-purine-6-thione;2-Amino-7H-purine-6-thiol;611-67-6;1125-65-1;1832-72-0;5632-51-9;153981-50-1;158476-00-7

CAS No.:

154-42-7

Molecular Formula:

C5H5N5S

InChIKeys:

InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N

Molecular Weight:

167.19

Exact Mass:

167.19

BRN:

157765

EC Number:

205-827-2

UNII:

WIX31ZPX66

NSC Number:

757348|752

UN Number:

2811

DSSTox ID:

DTXSID6023652

NCI Thesaurus Code:

C61970

Color/Form:

NEEDLES FROM WATER|YELLOW, CRYSTALLINE POWDER

ATC Code:

L - Antineoplastic and immunomodulating agents

HScode:

29335990

Categories:

Antineoplastic Agents

Characteristics

PSA:

111

XLogP3:

-0.1

Appearance:

Yellow to green lyophilized powder

Density:

1.483 (estimate)

Melting Point:

>360 °C

Boiling Point:

555.4±42.0 °C(Predicted)

Flash Point:

232.4±26.5 °C

Refractive Index:

1.5605 (estimate)

Water Solubility:

Readily soluble in dilute aqueous alkali. Insoluble in water, alcohol, or chloroform.

Storage Conditions:

Store at RT.

Vapor Pressure:

1.5E-17mmHg at 25°C

Toxicity:

Peritoneal-rat LD50: 300 mg/kg; oral-mouse LD50: 160 mg/kg

Flammability characteristics:

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Odor:

ODORLESS OR PRACTICALLY ODORLESS

Collision Cross Section:

129.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Air and Water Reactions:

This chemical may be sensitive to prolonged exposure to air. Insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

6-THIOGUANINE is incompatible with strong oxidizing agents. (NTP, 1992).

See More Thioguanine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Thioguanine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

Location:
https://www.dideu.com/en/

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
Above $100 million

Total Employees:
Above 1000

Year of Establishment:
2016

Certifications:
ISO Certificate,REACH

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