Native Human Topoisomerase I
1 Inquiries
80449-01-0
Yes
2026-11-15
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Native Human Topoisomerase I Cat No NATE-0707 Description Topoisomerase I relaxes supercoiled DNA molecules. The enzyme initiates transient breakages and rejoins of phosphodiester bonds in superhelical turns of closed-circular DNA. Enzyme activity is independent of right-and left-handed superhelices. Abbr TOPO I, Native (Human) Alias TOPO I; ω-protein Source Human Applications Topoisomerase I has been used in a study to assess implications for the regulation of HIV-1 replication. Topoisomerase I has also been used in a study to investigate the tumor suppressor protein kinase Chk2 is a mediator of anoikis of intestinal epithelial cells. Product Overview Cellular topoisomerase I is present in retroviral particles and enhances viral cDNA synthesis. Form buffered aqueous glycerol solution; Solution containing 20 mM sodium phosphate, pH 7.4, 300 mM NaCl, 50 μg/mL BSA, 50% glycerol, and between 25-100 mM imidazole (concentration will be lot dependent). Enzyme Commission Number EC 5.99.1.2 Activity > 2 units/μL CAS No 80449-01-0 Molecular Weight mol wt 100 kDa Unit Definition One unit will relax 0.25 μg of supercoiled plasmid DNA in 30 minutes at pH 7.9 at 37°C. Storage −70°C Pathway Caspase cascade in apoptosis, organism-specific biosystem Function ATP binding; DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA topoisomerase type I activity; chromatin DNA binding; chromatin binding; nucleotide binding; protein binding Synonyms Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I category Specialty Chemicals(c26) cas_num 80449-01-0 Basic Info-
Product Name:
TOPOISOMERASEI
Other Name:TOPO I;TOPOISOMERASE I;DNA TOPOISOMERASE I;dna relaxing enzyme;Topoisomerase I, hl-60 cell;Topoisomerase I, L1210 cell;Topoisomerase I, calf thymus;topoisomerase I from wheat germ;Dna topoisomerase I, calf thymus;Dna topoisomerase ii, calf thymus
CAS No.:80449-01-0
Molecular Formula:C20H27N3O
InChIKeys:OVFMPNAYXDYMBS-BCZMGUNLSA-N
Molecular Weight:325.44788
Exact Mass:325.215
Categories:
Characteristics-
PSA:
58.4
XLogP3:2.8
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
Native Wheat germ Topoisomerase I
500 Apr 28, 2026 Post an enquiry for this product
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