7-Ethoxycoumarin-3-carbonitrile
117620-77-6
2026-08-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName 7-Ethoxycoumarin-3-carbonitrile Cat No CSUB-0194 Applications This reagent is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. The product of the reaction is the fluorescent compound 3-cyano-7-hydroxycoumarin (Product No. C 2737). This property has been utilized to determine the activity of CYP1A by measuring the rate of dealkylation of 3-Cyano-7-ethoxycoumarin to this fluorescent product . Fluorescence of 3-cyano-7-hydroxycoumarin occurs at neutral pH with excitation and emission at 408 and 450 nm, respectively . Fluorescent reaction product detection is at least 50-fold more sensitive than that of the product of alkyl resorufin oxidation because of greater rate of turnover of 3-Cyano-7-ethoxycoumarin . The ability to continuously monitor the enzyme reaction at pH 7 is derived from the lower pKa of the 3-cyano-7- hydroxycoumarin product compared to that for 7-ethoxycoumarin . 3-Cyano-7-ethoxycoumarin is a suitable substrate for three of the five principal cytochrome P450 drug metabolizing enzymes, CYP1A1, CYP1A2, CYP2C9, and CYP2C19 . It has been used to measure cytochrome P450 mixed-function monooxygenases in rat hepatic microsomal preparations as well as in isolated rat hepatocytes . It was part of a study to examine the expression of CYP2B6 in human liver microsomes, and has been used to characterize Clara and type II cells from rat lung. CAS No 117620-77-6 Molecular Weight 215.2 Synonyms 3-Cyano-7-ethoxycoumarin Molecular Formula C12H9NO3 MDL Number MFCD00467359 Solubility DMSO: soluble PubChem Substance ID 24845687.0 Substrates Cytochrome P450 Impurities λex 324 nm; λem 414 nm in DMSO category Heterocyclic Compound(c1111) cas_num 117620-77-6 Basic Info-
Product Name:
3-CYANO-7-ETHOXYCOUMARIN
Other Name:7-ETHOXYCOUMARIN-3-CARBONITRILE;3-CYANO-7-ETHOXYCOUMARIN;2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI);7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile;3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*
CAS No.:117620-77-6
Molecular Formula:C12H9NO3
InChIKeys:YAFGHMIAFYQSCF-UHFFFAOYSA-N
Molecular Weight:215.2
Exact Mass:215.058243
UNII:997LV3DUS7
DSSTox ID:DTXSID00151844
HScode:2932209090
Categories:
Characteristics-
PSA:
59.3
XLogP3:2.2
Appearance:yellow to orange
Density:1.3±0.1 g/cm3
Melting Point:220-221ºC
Flash Point:173.6±18.1 °C
Refractive Index:1.588
Water Solubility:DMSO: soluble
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Skin irritation, Category 2
Eye irritation, Category 2
Acute toxicity - Category 4, Inhalation
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
