CCT128930
885499-61-6
99%
2026-07-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CCT128930 Cat No CEI-0089 Description CCT128930 is a novel ATP-competitive AKT2 inhibitor with IC50 of 6 nM. CAS No 885499-61-6 Molecular Weight 341.84 Purity >99% Storage 2 years at -20 centigrade Targets Akt2 Molecular Formula C18H20ClN5 Chemical Name 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine Solubility DSMO 68 mg/mL Water In vitro CCT128930 is a novel ATP-competitive AKT2 inhibitor with IC50 of 6 nM. CCT128930 is a high selective inhibitor with a 28-fold selectivity over the closely related PKA kinase. CCT128930 inhibit PKA and p70S6K with IC50 of 168 nM and 120 nM. CCT128930 inhibit the growth of U87MG human glioblastoma cells, LNCaP human prostate cancer cells and PC3 human prostate cancer cells with IC50 of 6.3 umol/L, 0.35 umol/L and 1.9 umol/L. CCT128930 can influence cell cycle by inhibiting akt. CCT128930 cause a predominant G1-phase arrest, with a corresponding decrease in S phase in PTEN-null U87MG human glioblastoma cells in a time- and drug concentration-dependent manner. In vivo In PTEN-null U87MG human glioblastoma xenografts and HER2-positive, PIK3CA-mutant BT474 human breast cancer xenografts, CCT128930 (25 mg/kg, 40 mg/kg) shows antitumor activity as a single agent. category Inhibitors(c1514) cas_num 885499-61-6 Basic Info-
Product Name:
CCT128930
Other Name:4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine;4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine;4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-;CCT128930, >=98%
CAS No.:885499-61-6
Molecular Formula:C18H20ClN5
InChIKeys:RZIDZIGAXXNODG-UHFFFAOYSA-N
Molecular Weight:341.8379
Exact Mass:341.140717
DSSTox ID:DTXSID80590818
Categories:
Characteristics-
PSA:
70.8
XLogP3:2.93
Density:1.3±0.1 g/cm3
Boiling Point:547.9±50.0 °C at 760 mmHg
Flash Point:285.2±30.1 °C
Refractive Index:1.680
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product