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CCT128930

CCT128930 structure

CAS No:
885499-61-6
Formula:
C18H20ClN5
Chemical Name:
CCT128930
Synonyms:
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine;4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine;4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-;CCT128930, >=98%
Categories:
Biochemical Engineering > Inhibitors

Description

CCT128930 is a potent and selective inhibitor of Akt2 (IC50 6 nM) with 28-fold selectivity over the closely related PKA kinase (IC50 168 nM), as well as 20-fold selectivity over p70S6K (IC50 120 nM).

CCT128930 Basic Attributes

Molecular Weight：

341.8379

Exact Mass：

341.140717

DSSTox ID：

DTXSID80590818

Characteristics

PSA：

70.8

XLogP3：

2.93

Density：

1.3±0.1 g/cm3

Boiling Point：

547.9±50.0 °C at 760 mmHg

Flash Point：

285.2±30.1 °C

Refractive Index：

1.680

Drug Information

MeSH Entry Terms：

4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine

CCT128930 Use and Manufacturing

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.

Computed Properties

Molecular Weight:341.8
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:341.1407234
Monoisotopic Mass:341.1407234
Topological Polar Surface Area:70.8
Heavy Atom Count:24
Complexity:418
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 885499-61-6

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Content: 99%

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