CCT128930
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CCT128930
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CAS No:
885499-61-6
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Formula:
C18H20ClN5
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Chemical Name:
CCT128930
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Synonyms:
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine;4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine;4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-;CCT128930, >=98%
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CAS No:
Description
CCT128930 is a potent and selective inhibitor of Akt2 (IC50 6 nM) with 28-fold selectivity over the closely related PKA kinase (IC50 168 nM), as well as 20-fold selectivity over p70S6K (IC50 120 nM).
CCT128930 Use and Manufacturing
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.
Computed Properties
Molecular Weight:341.8
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:341.1407234
Monoisotopic Mass:341.1407234
Topological Polar Surface Area:70.8
Heavy Atom Count:24
Complexity:418
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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