3-Methyladenine
5142-23-4
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName 3-Methyladenine Cat No CEI-0099 Description 3-Methyladenine Alias 3-MA CAS No 5142-23-4 Molecular Weight 149.15 Purity >99% Storage 2 years at -20centigrade Powder Synonyms 3-MA Targets PI3K Molecular Formula C6H7N5 Chemical Name 3-methyl-3H-purin-6-amine Solubility DMSO 4 mg/mL, Water In vitro The slight preference for Vps34 prevention by 3-Methyladenine probably arises from a hydrophobic ring specific to Vps34, which encircles the 3-methyl group of 3-Methyladenine. 3-Methyladenine has been reported to cause cancer cell death under both normal and starvation conditions. 3-Methyladenine could also suppress cell migration and invasion independently of its ability to inhibit autophagy, implying that 3-Methyladenine possesses functions other than autophagy suppression. 3-Methyladenine elicits caspase-dependent cell death that is independent of autophagy inhibition. Treatment with 5 mM 3-Methyladenine reduces the percentage of glucose-starved HeLa cells displaying GFP-LC3 puncta to 23%. The levels of LC3-I are increasing and the levels of LC3-II are decreasing between 12 and 48 hours in cells that are treated with 3-Methyladenine. Conversion of LC3-I to LC3-II is suppressed by 3-Methyladenine. Treatment of HeLa cells with 3-Methyladenine at 2.5 mM or 5 mM for one day does not affect cell viability, whereas treatment with 10 mM 3-Methyladenine for one day causes a 25.0% decrease in cell viability. Treatment of cells with 2.5, 5 or 10 mM 3-Methyladenine for two days causes 11.5%, 38.0% and 79.4% decrease in viability, respectively. 3-Methyladenine decreases cell viability in a time- and dose-dependent manner. 3-Methyladenine significantly shortens the duration of nocodazole-induced-prometaphase arrest. category Nucleoside Drugs(c1520) cas_num 5142-23-4 Basic Info-
Product Name:
3-Methyladenine
Other Name:3H-Purin-6-amine,3-methyl-;Adenine,3-methyl-;3-Methyl-3H-purin-6-amine;3-Methyladenine;N3-Methyladenine;6-Amino-3-methylpurine;3-Methyl-6-aminopurine;NSC 66389;3-Methyl-3H-purin-6-ylamine;3-Methylpurin-6-amine
CAS No.:5142-23-4
Molecular Formula:C6H7N5
InChIKeys:InChIKey=FSASIHFSFGAIJM-UHFFFAOYSA-N
Molecular Weight:149.15
Exact Mass:149.15
EC Number:225-908-6
UNII:DR88TV7SNU|3899G64TKW
NSC Number:66389
DSSTox ID:DTXSID80199406
HScode:2933990090
Categories:
Characteristics-
PSA:
69.6
XLogP3:-0.6
Appearance:White Powder
Density:1.6±0.1 g/cm3
Melting Point:300 °C
Boiling Point:240℃
Flash Point:99℃
Refractive Index:1.807
Storage Conditions:Store at +4°C
Vapor Pressure:1.20e-09 mmHg
Collision Cross Section:126.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|126.5 Ų [M+H]+
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
