PHT-427
1191951-57-1
99%
2026-08-04
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PHT-427 Cat No CEI-0103 Description PHT-427 CAS No 1191951-57-1 Molecular Weight 409.61 Purity >99% Storage 2 years at -20 centigrade Targets Akt, PDPK1 Molecular Formula C20H31N3O2S2 Solubility No In vitro PHT-427 can inhibit both Akt and PDPK1 with Ki values of 2.7 uM and 5.2 uM. PHT-427 itself (C-12 chain) bound with the highest affinity to the PH domains of both PDPK1 and Akt. PHT-427 inhibited Akt and PDKP1 signaling and their downstream targets in sensitive but not resistant cells and tumor xenografts. The PDPK1-independent phospho-Ser473-Akt was slightly increased by PHT-427, but completely inhibited in by wortmannin. Phospho-Ser657-protein kinase C (PKC) and total SGK1 are decreased by treatment with both PHT-427 and wortmannin. In the BxPC-3 cells which is sensitive to the antitumor activity of PHT-427, shows a decrease of both phospho-Ser473-Akt and phospho-Thr308-Akt. category Inhibitors(c1514) cas_num 1191951-57-1 Basic Info-
Product Name:
4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
Other Name:Benzenesulfonamide,4-dodecyl-N-1,3,4-thiadiazol-2-yl-;4-Dodecyl-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;PHT 427;1178893-77-0
CAS No.:1191951-57-1
Molecular Formula:C20H31N3O2S2
InChIKeys:InChIKey=BYWWNRBKPCPJMG-UHFFFAOYSA-N
Molecular Weight:409.62
Exact Mass:409.61
UNII:543K8ZN6LH
DSSTox ID:DTXSID90658014
Categories:
Characteristics-
PSA:
109
XLogP3:7.4
Density:1.162
Melting Point:126-127 °C @ Solvent: Hexane, Ethyl acetate
Boiling Point:535.0±43.0 °C(Predicted)
Flash Point:277.4±28.2 °C
Refractive Index:1.556
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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