CP-466722
1080622-86-1
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CP-466722 Cat No CEI-0109 Description CP-466722, a nontoxic compound, is a ATM protein kinase inhibitor and shows no inhibition to PI3K, PI3K-like protein kinases or Abl kinase in cells. CAS No 1080622-86-1 Molecular Weight 349.35 Purity >99% Storage 2 years at -20 centigrade Targets ATM Molecular Formula C17H15N7O2 Chemical Name 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine Solubility DSMO 0.28 mg/mL Water In vitro CP-466722, a nontoxic compound, is a ATM protein kinase inhibitor and shows no inhibition to PI3K, PI3K-like protein kinases or Abl kinase in cells.CP466722 inhibits ATM function in response to IR-induced DNA damage. As ATM kinase can activate signal transduction pathways essential for coordinating cell cycle progression with DNA repair, CP-466722 induces characteristic cell cycle checkpoint defects by disrupting ATM function and inhibiting cellular ATM-dependent phosphorylation. Removing CP466722 lead to reversion of inhibition of cellular ATM kinase activity. In vivo While KU-55933 did not enhance TMZ induced Chk1/Chk2 activation, it increased TMZ-induced residual gamma-H2AX foci in the parental cells but not in the TMZ resistant cells. Similar sensitization was observed with CP-466722 combined with TMZ in GBM12 xenograft line but not in GBM12TMZ, which is resistant to TMZ due to MGMT overexpression. category Inhibitors(c1514) cas_num 1080622-86-1 Basic Info-
Product Name:
CP466722
Other Name:CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
CAS No.:1080622-86-1
Molecular Formula:C17H15N7O2
InChIKeys:ILBRKJBKDGCSCB-UHFFFAOYSA-N
Molecular Weight:349.35
Exact Mass:349.128723
EC Number:-0
Categories:
Characteristics-
PSA:
114
XLogP3:0.83
Appearance:white to beige
Density:1.48
Boiling Point:642.3±65.0 °C(Predicted)
Flash Point:342.2±34.3 °C
Refractive Index:1.737
Water Solubility:DMSO: soluble0.5mg/mL, clear (warmed)
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product