AT7867
857531-00-1
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AT7867 Cat No CEI-0110 Description As an ATP-competitive inhibitor, AT7867 can potently Akt1, Akt2, Akt3 and S6K with IC50 of 32 nM, 17 nM, 47 nM and 85 nM. CAS No 857531-00-1 Molecular Weight 337.85 Purity >99% Storage 2 years at -20 centigrade Targets Akt1, Akt2, Akt3, S6K Molecular Formula C20H20ClN3 Chemical Name 4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine Solubility DSMO 68 mg/mL Water In vitro As an ATP-competitive small molecule inhibitor, AT7867 can potently inhibitor of Akt, p70S6 kinase and PKA. AT7867 can also blocked proliferation in a number of human cancer cell lines which exhibit deregulation of the PI3K/AKT pathway by mechanisms, such as PTEN or PIK3CA mutations. In addition, the MES-SA uterine cell line seemed to be the most sensitive to growth inhibition by AT7867. In vivo In MES-SA tumor xenografts, doses of AT7867 (90 mg/kg p.o. or 20 mg/kg i.p.) were given to athymic mice bearing MES-SA tumors. Clear inhibition of phosphorylation of GSK3betaand S6RP in tumors was seen at 2 and 6 hours following treatment with AT7867 and AT7867 can induce an increase in cleaved PARP, leading to inducing apoptosis in the xenograft tumor cells. category Inhibitors(c1514) cas_num 857531-00-1 Basic Info-
Product Name:
AT7867
Other Name:AT7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;AT-7867(AT7867);4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidineAT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
CAS No.:857531-00-1
Molecular Formula:C20H20ClN3
InChIKeys:LZMOSYUFVYJEPY-UHFFFAOYSA-N
Molecular Weight:337.86
Exact Mass:337.134583
EC Number:-0
UNII:ERF7YL2CE2
DSSTox ID:DTXSID00457772
Categories:
Characteristics-
PSA:
40.7
XLogP3:4.3
Density:1.2±0.1 g/cm3
Boiling Point:530.2ºC at 760 mmHg
Flash Point:274.5±30.1 °C
Refractive Index:1.616
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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