AT7867
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AT7867
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CAS No:
857531-00-1
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Formula:
C20H20ClN3
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Chemical Name:
AT7867
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Synonyms:
AT7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;AT-7867(AT7867);4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidineAT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
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CAS No:
Description
AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.
AT7867 is a member of the class of piperidines carrying two aryl substituents (4-chlorophenyl and 4-(pyrazol-4-yl)phenyl) at position 4. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of piperidines and a member of monochlorobenzenes.
AT7867 Use and Manufacturing
A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.
Computed Properties
Molecular Weight:337.8
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:337.1345753
Monoisotopic Mass:337.1345753
Topological Polar Surface Area:40.7
Heavy Atom Count:24
Complexity:394
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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