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AT7867

AT7867 structure

CAS No:
857531-00-1
Formula:
C20H20ClN3
Chemical Name:
AT7867
Synonyms:
AT7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;AT-7867(AT7867);4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidineAT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
Categories:
Biochemical Engineering > Inhibitors

Description

AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively.

AT7867 is a member of the class of piperidines carrying two aryl substituents (4-chlorophenyl and 4-(pyrazol-4-yl)phenyl) at position 4. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of piperidines and a member of monochlorobenzenes.

AT7867 Basic Attributes

Molecular Weight：

337.86

Exact Mass：

337.134583

EC Number：

-0

UNII：

ERF7YL2CE2

DSSTox ID：

DTXSID00457772

Characteristics

PSA：

40.7

XLogP3：

4.3

Density：

1.2±0.1 g/cm3

Boiling Point：

530.2ºC at 760 mmHg

Flash Point：

274.5±30.1 °C

Refractive Index：

1.616

Drug Information

MeSH Entry Terms：

AT 7867

AT7867 Use and Manufacturing

A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.

Computed Properties

Molecular Weight:337.8
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:337.1345753
Monoisotopic Mass:337.1345753
Topological Polar Surface Area:40.7
Heavy Atom Count:24
Complexity:394
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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AT7867

CAS No.: 857531-00-1

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