XL765
1349796-36-6
99%
2026-08-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName XL765 Cat No CEI-0111 Description As a dual inhibitor of mTOR/PI3k, XL765 shows inhibition to mTOR, p110alpha, p110beta, p110gamma and p110delta with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM. Alias SAR245409 CAS No 1349796-36-6 Molecular Weight 599.66 Purity >99% Storage 2 years at -20 centigrade Synonyms SAR245409 Targets MTOR, p110alpha, p110beta, p110gamma, p110delta Molecular Formula C31H29N5O6S Chemical Name Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl- Solubility DSMO 15 mg/mL Water In vitro As a dual inhibitor of mTOR/PI3k, XL765 shows inhibition to mTOR, p110alpha, p110beta, p110gamma and p110delta with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM. XL765 treatment results in decreased cell viability in 13 PDA cell lines in a dose-dependent manner. XL765, a dual-target PI3K/mTOR inhibitor, inhibits cell growth and apoptosis in many more cell lines and at lower concentrations as compared to the PI3K-selective inhibitors XL147 and PIK90. In vivo The combination of XL765 (30 mg/kg) with chloroquine (50 mg/kg) results in significant inhibition of BxPC-3 xenograft growth in mice models, while XL765 alone at the same dose has no inhibitory effect. category Inhibitors(c1514) cas_num 1349796-36-6 Basic Info-
Product Name:
XL765
Other Name:SAR245409 (XL765);PI3K-IN-1;N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-;Voxtalisib (SAR245409, XL765);N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide SAR245409 (XL765);XL765 N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;XL765, >=98%
CAS No.:1349796-36-6
Molecular Formula:C31H29N5O6S
InChIKeys:HJSSPYJVWLTYHG-UHFFFAOYSA-N
Molecular Weight:599.65686
Exact Mass:599.184
Categories:
Characteristics-
PSA:
149
XLogP3:5.1
Density:1.387±0.06 g/cm3(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product