KU-55933
587871-26-9
99%
2026-07-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName KU-55933 Cat No CEI-0120 Description KU-55933 can inhibit ATM with IC50 of 13 nM. CAS No 587871-26-9 Molecular Weight 395.49 Purity >99% Storage 2 years at -20centigrade Powder Targets ATM Molecular Formula C21H17NO3S2 Chemical Name 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one Solubility DMSO 50 mg/mL Water In vitro As a specific ATM (Ataxia telangiectasia mutated kinase) inhibitor, KU-55933, blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Through the downregulation of the synthesis of cyclin D1, KU-55933 induces G1 cell cycle arrest, resulting in inhibiting cancer cell proliferation. KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Combining KU-55933 with rapamycin may provide a highly effective approach for improving mammalian target of rapamycin-targeted anticancer therapy that is currently hindered by rapamycin-induced feedback activation of Akt. In parental U251 and U87 glioma lines, the addition of KU-55933 to TMZ significantly increased cell killing compared to TMZ alone, But KU-55933 did not sensitize the resistant lines to TMZ, and neither TMZ alone or combined with KU-55933 induced a G2/M arrest. category Inhibitors(c1514) cas_num 587871-26-9 Basic Info-
Product Name:
KU-55933
Other Name:2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE;2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one;KU-55933 (ATM Kinase Inhibitor);KU-55933, >99%;KV-55933;2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor);KU 55933, >=98%
CAS No.:587871-26-9
Molecular Formula:C21H17NO3S2
InChIKeys:XRKYMMUGXMWDAO-UHFFFAOYSA-N
Molecular Weight:395.49
Exact Mass:395.064972
UNII:O549494L5D
DSSTox ID:DTXSID40207516
Categories:
Characteristics-
PSA:
89.4
XLogP3:3.9
Density:1.4±0.1 g/cm3
Boiling Point:628°C at 760 mmHg
Flash Point:333.6±31.5 °C
Refractive Index:1.714
Storage Conditions:Desiccate at -20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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