GSK2126458
1086062-66-9
99%
2026-07-19
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName GSK2126458 Cat No CEI-0134 Description GSK2126458 can inhibit p110alpha p110beta,p110gamma, p110delta, mTORC1,mTORC2 with IC50 of 0.019nM, 0.13 nM, 0.024 nM,0.06 nM, 0.18 nM, and 0.3 nM. CAS No 1086062-66-9 Molecular Weight 505.5 Purity >99% Storage 2 years at -20centigrade Powder Targets p110alpha, p110beta, p110gamma, p110delta, mTORC1/mTORC2 Molecular Formula C25H17F2N5O3S Chemical Name 2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide Solubility DMSO 101 mg/mL Water In vitro GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymesand MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC50 of 0.04 nM. GSK2126458 has Ki values in the picomolar range for each of the class I PI3K isoforms and MTOR1/2 complexes. GSK2126458 has potent in vitro and in vivo growth-inhibitory effects on cancer cells. In comparison with other clinical PI3K inhibitors, GSK2126458 is around 100-fold more potent than BEZ235 ( 6 nM ). GSK2126458 also a low picomolar inhibitor of the common activating mutants of p110 R ( E542K, E545K, and H1047R ) with Ki of 0.008 nM, 0.008 nM and 0.009 nM in human cancer. In mechanistic cellular assays, GSK2126458 caused a significant reduction in the levels of pAKT-S473 with remarkable potency. Consistent with its activity against both PI3K R and mTOR, GSK2126458 also inhibits phosphorylation of AKT-T308 and p70S6K at low nanomolar concentrations. GSK2126458 induces a G1 cell cycle arrest and inhibits cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines. category Inhibitors(c1514) cas_num 1086062-66-9 Basic Info-
Product Name:
Omipalisib
Other Name:Benzenesulfonamide,2,4-difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]-;2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide;GSK 2126458;Omipalisib;GSK 458
CAS No.:1086062-66-9
Molecular Formula:C25H17F2N5O3S
InChIKeys:InChIKey=CGBJSGAELGCMKE-UHFFFAOYSA-N
Molecular Weight:505.4959864
Exact Mass:505.50
EC Number:-0
UNII:1X8F5A3NA0
DSSTox ID:DTXSID10148604
NCI Thesaurus Code:C88270
HScode:29350090
Categories:
Characteristics-
PSA:
115
XLogP3:3.3
Density:1.45
Melting Point:187-189 °C
Boiling Point:715.6±70.0 °C(Predicted)
Flash Point:386.6±35.7 °C
Refractive Index:1.660
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Germ cell mutagenicity, Category 2
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H341 Suspected of causing genetic defects
H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product