OSI-027
936890-98-1
99%
2026-08-08
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName OSI-027 Cat No CEI-0137 Description OSI-027 can inhibit mTORC1, mTORC2 and mTOR with IC50 of 22 nM, 65 nM and 4 nM. CAS No 936890-98-1 Molecular Weight 406.44 Purity >99% Storage 2 years at -20centigrade Powder Targets mTORC1, mTORC2, mTOR Molecular Formula C21H22N6O3 Chemical Name (1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid Solubility DMSO 18 mg/mL, Water In vitro OSI-027 is a potent, selective small molecule inhibitor of the catalytic site of mTOR, targeting both mTORC1 and mTORC2. OSI-027 can inhibit mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM. OSI-027 can inhibit phosphorylation of AKT at S473 and T308 in a concentration-dependent manner in BT-474 and IGR-OV1 cells under normal culture conditions and in MDA-MB-231 cells upon insulin stimulation..OSI-027 potently inhibits proliferation and induces apoptosis in cells expressing the T315I-BCR-ABL mutation. OSI-027 can dose-dependently attenuate Akt phosphorylation at the mTORC2-specific Ser473 site and the downstream substrate of Akt, PRAS40. In vivo Treated with OSI-027 in GEO colorectal xenograft model, OSI-027 (65 mg/kg) inhibited both mTORC1 and mTORC2 effectors. After 2 hours, decreased 4E-BP1, Akt, and S6 phosphorylation was observed and inhibition of S6 andAkt was sustained for 24 hours. category Inhibitors(c1514) cas_num 936890-98-1 Basic Info-
Product Name:
OSI-027
Other Name:OSI-027;trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid;4-(4-aMino-5-(7-Methoxy-1H-indol-2-yl)-1,2-dihydroiMidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride;4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f] [1,2,4]Triazin-7-yl)cyclohexanecarboxylic Acid;(1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid;ASP4786;OSI-027trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid;trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acidOSI-027
CAS No.:936890-98-1
Molecular Formula:C21H22ClN6O3
InChIKeys:JROFGZPOBKIAEW-UHFFFAOYSA-N
Molecular Weight:441.89078
Exact Mass:406.175354
EC Number:-0
UNII:25MKH1SZ0M
NCI Thesaurus Code:C78476
Categories:
Characteristics-
PSA:
131.42000
XLogP3:3.80300
Density:1.6±0.1 g/cm3
Flash Point:311.5±32.9 °C
Refractive Index:1.788
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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