PF-04691502
1013101-36-4
99%
2026-08-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PF-04691502 Cat No CEI-0138 Description PF-04691502 inhibits PI3K-alpha, PI3K-beta, PI3K-delta, PI3K-gamma, and mTOR with Ki of 1.8 nM, 2.1 nM, 1.6 nM, and 1.9 nM and 16 nM. CAS No 1013101-36-4 Molecular Weight 425.48 Purity >99% Storage 2 years at -20centigrade Powder Targets PI3K, mTOR Molecular Formula C22H27N5O4 Chemical Name 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one Solubility DMSO 14 mg/mL Water In vitro PF-04691502 is an ATP-competitive, selective inhibitor of Class I PI3K and mTOR. PF-04691502 inhibits PI3K-alpha, PI3K-beta, PI3K-delta, PI3K-gamma, and mTOR with Ki of 1.8 nM, 2.1 nM, 1.6 nM, and 1.9 nM and 16 nmol/L. PF-04691502 inhibits PI3K/mTOR signaling and induces cell cycle arrest in cancer cell. PF-04691502 can induce cell cycle arrest at the G1 phase in a dose-dependent manner in U87MG cells. Besides above, PF-04691502 can modestly increase caspase 3/7 activities ( 3-fold) in a dose-dependent manner in U87MG cells. For cell linePF-04691502 inhibits cell proliferation of BT20, SKOV3, and U87MG with IC 50 values of 313 nM, 188 nM, and 179 nM. In vivo In a U87MG xenograft model, treatment with 10 mg/kg PF-04691502 resulted in a significant reduction of P-AKT(S473) levels at 1 hour postdosing, and persistent inhibition was observed for 8 hours PF-04691502 also shows robust antitumor activity in ovarian cancer and NSCLC models. The effect of PF-04691502 was also measured in a time-dependent manner at 1, 7, and 24 hours post 10 mg/kg dose. Phosphorylation of AKTS473, PRAS40, 4EBP1, and S6RP was inhibited up to 7 hours after dosing. category Heterocyclic Compound(c1111) cas_num 1013101-36-4 Basic Info-
Product Name:
PF-04691502
Other Name:PF-04691502;2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-aMino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-Methoxypyridin-3-yl)-4-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;PF-046915022-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3
CAS No.:1013101-36-4
Molecular Formula:C22H27N5O4
InChIKeys:XDLYKKIQACFMJG-UHFFFAOYSA-N
Molecular Weight:425.48088
Exact Mass:425.206299
UNII:4W39NS61KI
Categories:
Characteristics-
PSA:
124
XLogP3:1.6
Density:1.36
Boiling Point:682.5±65.0 °C(Predicted)
Flash Point:366.5±34.3 °C
Refractive Index:1.646
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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