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PF-04691502

PF-04691502 structure

CAS No:
1013101-36-4
Formula:
C22H27N5O4
Chemical Name:
PF-04691502
Synonyms:
PF-04691502;2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-aMino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-Methoxypyridin-3-yl)-4-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;PF-046915022-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Pale Yellow Solid

PF-04691502 has been used in trials studying the treatment of Cancer, Breast Neoplasms, Early Breast Cancer (Phase 2), and Advanced Breast Cancer (Phase 1b).

PF-04691502 Basic Attributes

Molecular Weight：

425.48088

Exact Mass：

425.206299

UNII：

4W39NS61KI

Characteristics

PSA：

124

XLogP3：

1.6

Density：

1.36

Boiling Point：

682.5±65.0 °C(Predicted)

Flash Point：

366.5±34.3 °C

Refractive Index：

1.646

Safety Information

Transport codes：

NONH for all modes of transport

Drug Information

MeSH Entry Terms：

2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one

PF-04691502 Use and Manufacturing

PF-04691502 is an ATP-competitive PI3K/mTOR inhibitor with IC50 of 32 nM and also inhibits Akt T308/S473 with IC50 of 7.5 nM/3.8 nM.

Computed Properties

Molecular Weight:425.5
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:425.20630436
Monoisotopic Mass:425.20630436
Topological Polar Surface Area:124
Heavy Atom Count:31
Complexity:654
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of PF-04691502

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

PF-04691502

CAS No.: 1013101-36-4

Content: 99.00%

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Creative Enzymes Contact Supplier

US
6 YRS

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Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

PF-04691502

CAS No.: 1013101-36-4

Content: 99%

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