MK2206(dihydrochloride)
1032350-13-2
99%
2026-08-22
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName MK2206(dihydrochloride) Cat No CEI-0143 Description MK-2206 can inhibit Akt1, Akt2, and Akt3 with IC50 of 8 nM, 12 nM, and 65 nM. CAS No 1032350-13-2 Molecular Weight 480.39 Purity >99% Storage 2 years at -20centigrade Powder Targets Akt1, Akt2, Akt3 Molecular Formula C25H21N5O.2HCL Chemical Name 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Solubility DMSO 14 mg/mL Water 1 mg/ml Ethanol In vitro MK-2206 can inhibit Akt1, Akt2, and Akt3 with IC50 of 8 nM, 12 nM, and 65 nM. As a novel allosteric Akt inhibitor, MK-2206 can synergistically inhibited cell proliferation of human cancer cell lines. MK-2206 causes growth inhibition of the eight cell lines with an IC50 that ranges between 3.4 and 28.6 umol/L. MK-2206 alone more potently inhibited the cell growth of Ras wild-type (WT) cell lines (A431, HCC827, and NCI-H292; IC50 s of 5.5, 4.3, and 5.2 umol/L, respectively) as compared with Ras-mutant cell lines (NCI-H358, NCI-H23, NCI-H1299, and Calu-6; IC50 s of 13.5, 14.1, 27.0, and 28.6 umol/L, respectively), with the exception of NCI-H460, which has a PIK3CA E545K mutation (IC50, 3.4 umol/L).In acute lymphoblastic leukemia, MK-2206 decreased T-ALL cell line viability by blocking leukemic cells in the G0/G1 phase of the cell cycle and inducing apoptosis. MK-2206 also induced autophagy. In acute lymphoblastic leukemia, MK-2206 lead to a concentration-dependent dephosphorylation of Akt and its downstream targets, GSK-3alpha/beta and FOXO3A. In Neuroblastoma, MK-2206 treatment inhibited NB cell proliferation which was accompanied by a cell line selective G1 arrest of cell cycle or production of ROS. In vivo Mice with xenografted tumors treated with MK-2206 alone or with progesterone alone exhibited modest reductions in their tumor volume. The Akt inhibitor (MK-2206) also inhibits increased NCC phosphorylation in db/db mice. category Inhibitors(c1514) cas_num 1032350-13-2 Basic Info-
Product Name:
MK 2206 dihydrochloride
Other Name:1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one,8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-,hydrochloride (1:2);MK 2206 dihydrochloride
CAS No.:1032350-13-2
Molecular Formula:C25H21N5O.2ClH
InChIKeys:InChIKey=HWUHTJIKQZZBRA-UHFFFAOYSA-N
Molecular Weight:407.46714
Exact Mass:479.127960
Categories:
Characteristics-
PSA:
83.6
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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