TAK-733
1035555-63-5
99%
2026-08-14
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName TAK-733 Cat No CEI-0146 Description As a novel allosteric, non-ATP-binding inhibitor, TAK-733 can potently and selectively inhibit MEK1/2 with IC50 of 3.2 nM. CAS No 1035555-63-5 Molecular Weight 504.23 Purity >99% Storage 2 years at -20 centigrade Targets MEK1/2 Molecular Formula C17H15F2IN4O4 Chemical Name (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione Solubility DSMO 101 mg/mL Water In vitro As a novel allosteric, non-ATP-binding inhibitor, TAK-733 can potently and selectively inhibit MEK1/2 with IC50 of 3.2 nM. TAK-733 belongs to 5-phenylamino-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione series compound.[1] TAK733 shows strong inhibition to uveal melanoma cell lines with IC50 around 10 nM. Some uveal melanoma cell line is sensitive to TAK733, with IC50 less than 1 nM. TAK733 can induce cell cycle arrest. For both TAK733-sensitive( M207) and TAK733-highly resistant cell line, TAK733,with increasing concentrations, can induce a dose-dependent G1 arrest. TAK733 can induce G1 arrest in melanoma cell lines regardless of their origin, driver oncogenic mutations and in vitro sensitivity to TAK733. TAK733 also can induce a marked dose-dependent decrease of pERK, regardless of the driver oncogenic mutation or the sensitivity or resistance. In vivo TAK-733 shows potent inhibition to mouse xenograft models of human cancer, such as melanoma, colorectal, NSCLC, pancreatic and breast cancer. category Inhibitors(c1514) cas_num 1035555-63-5 Basic Info-
Product Name:
TAK-733
Other Name:TAK-733;TAK-733/TAK733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dioneTAK 733;(R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrim
CAS No.:1035555-63-5
Molecular Formula:C17H15F2IN4O4
InChIKeys:RCLQNICOARASSR-SECBINFHSA-N
Molecular Weight:504.2266764
Exact Mass:504.011
UNII:5J61HSP0QJ
DSSTox ID:DTXSID20648089
NCI Thesaurus Code:C84858
Categories:
Characteristics-
PSA:
106
XLogP3:0.9
Density:1.91±0.1 g/cm3(Predicted)
Boiling Point:530.5±60.0 °C(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product