AZD8330
869357-68-6
99%
2026-06-29
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AZD8330 Cat No CEI-0147 Description AZD8330 can inhibit MEK1/2 with IC50 of 7nM. CAS No 869357-68-6 Molecular Weight 461.23 Purity >99% Storage 2 years at -20 centigrade Targets MEK1/2 Molecular Formula C16H17FIN3O4 Chemical Name 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide Solubility DSMO 92 mg/mL Water In vitro AZD8330 (ARRY-424704),a potent and selective uncompetitive inhibitor, can inhibit MEK1/2 with IC50 of 7 nM and shows inhibition to ERK phosphorylation in Malme-3M cells with IC50 of 0.4 nM.AZD8330 (ARRY-424704) shows sub-nM inhibition of Ras/Raf/MEK/ERK signaling in tumor cell lines and low to sub-nM potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines. AZD8330 (ARRY-424704) also inhibit HT29 cell viability, Calu-6 cell viability, and Colo205 cell viability with IC50 of 3.8 nM, 11 nM and 0.7 nM. In tumor cell line panels AZD8330 demonstrates a similar pattern of activity with respect to BRAF and RAS gene mutation status to other MEK 1/2 inhibitors (AZD6244 and PD-0325901). In vivo In two nude rat human tumor xenograft models, AZD8330 (oral doses:0.4 mg/kg) shows significant anti-tumor efficacy. category Heterocyclic Compound(c1111) cas_num 869357-68-6 Basic Info-
Product Name:
ARRY-424704, ARRY-704
Other Name:ARRY-424704, ARRY-704;AZD8330;2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide;ARRY424704;ARRY-424704;ARRY704;ARRY-704;AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330
CAS No.:869357-68-6
Molecular Formula:C16H17FIN3O4
InChIKeys:RWEVIPRMPFNTLO-UHFFFAOYSA-N
Molecular Weight:461.23
Exact Mass:461.024780
EC Number:-0
UNII:G4990BOZ66
DSSTox ID:DTXSID50235986
Categories:
Characteristics-
PSA:
90.9
XLogP3:2.05
Density:1.7±0.1 g/cm3
Refractive Index:1.659
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product