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ARRY-424704, ARRY-704

ARRY-424704, ARRY-704 structure

CAS No:
869357-68-6
Formula:
C16H17FIN3O4
Chemical Name:
ARRY-424704, ARRY-704
Synonyms:
ARRY-424704, ARRY-704;AZD8330;2-(2-Fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide;ARRY424704;ARRY-424704;ARRY704;ARRY-704;AZD8330/ARRY-424704/arry-704/AZD8330/AZD-8330
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.

2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It derives from a nicotinamide.|AZD-8330 is a potent, selective, orally active MEK inhibitor that blocks signal transduction pathways implicated in cancer cell proliferation and survival. AZD-8330 has shown tumor suppressive activity in multiple preclinical models of human cancer including melanoma, pancreatic, colon, lung, and breast cancers.

ARRY-424704, ARRY-704 Basic Attributes

Molecular Weight：

461.23

Exact Mass：

461.024780

EC Number：

-0

UNII：

G4990BOZ66

DSSTox ID：

DTXSID50235986

Characteristics

PSA：

90.9

XLogP3：

2.05

Density：

1.7±0.1 g/cm3

Refractive Index：

1.659

Safety Information

Precautionary statement(s)：

P260, P264, P270, P301+P310, P314, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P301+P310, P314, P321, P330, P405, and P501|Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Investigated for use/treatment in cancer/tumors (unspecified).

Mechanism of Action：

AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

MeSH Entry Terms：

2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Computed Properties

Molecular Weight:461.23
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:461.02478
Monoisotopic Mass:461.02478
Topological Polar Surface Area:90.9
Heavy Atom Count:25
Complexity:596
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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