ZM 336372
208260-29-1
99%
2026-06-28
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName ZM 336372 Cat No CEI-0148 Description ZM 336372 can potently and selectivley inhibit c-Raf with IC50 of 70 nM. CAS No 208260-29-1 Molecular Weight 389.45 Purity >99% Storage 2 years at -20 centigrade Targets c-Raf Molecular Formula C23H23N3O3 Chemical Name Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]- Solubility DSMO 78 mg/mL Water In vitro ZM 336372 can potently and selectivley inhibit c-Raf with IC50 of 70 nM. But exposure of cells to ZM 336372 induces > 100-fold activation of c-Raf. The activation of c-Raf induced by ZM 336372 does not increase the GTP-loading of Ras. And this activation can not be blocked by inhibiting of the MAPK cascade, PKC or PI3K signaling. ZM 336372 does not prevent growth factor or phorbol ester induced activation of MKK1 or p42 MAPK/ERK2, or reverse the phenotype of Ras- or Raf-transformed cell lines. The only other protein kinase inhibited by ZM 336372 out of 20 tested was SAPK2/p38. In addition, the down-regulation of Pgp following BSO treatment can be abolished by c-Raf inhibitor ZM 336372. category Inhibitors(c1514) cas_num 208260-29-1 Basic Info-
Product Name:
ZM 336372
Other Name:N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;ZM 336372;3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE;Zinc00581684;3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide;Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-;ZM 3363723-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide;ZM 336372, >=98%
CAS No.:208260-29-1
Molecular Formula:C23H23N3O3
InChIKeys:PYEFPDQFAZNXLI-UHFFFAOYSA-N
Molecular Weight:389.45
Exact Mass:389.173950
DSSTox ID:DTXSID70274478
Categories:
Characteristics-
PSA:
81.7
XLogP3:3.7
Appearance:white to beige
Density:1.3±0.1 g/cm3
Boiling Point:484.4°C at 760 mmHg
Flash Point:246.8±28.7 °C
Refractive Index:1.704
Water Solubility:DMSO: >5mg/mL (warmed)
Storage Conditions:-20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product