BIX 02189
1094614-85-3
99%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BIX 02189 Cat No CEI-0152 Description As a selective inhibitor, BIX02189 can inhibit MEK5 with IC50 of 1.5 nM. CAS No 1094614-85-3 Molecular Weight 440.54 Purity >99% Storage 2 years at -20 centigrade Targets MEK5 Molecular Formula C27H28N4O2 Chemical Name (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide Solubility DSMO 88 mg/mL Water In vitro BIX02189 can inhibit MEK5 and ERK5 catalytic activity with IC50 values of 1.5 nM and 59 nM, respectively. They are more potent than the effect caused by BIX02188 with IC50 values of 4.3 nM and 830 nM. BIX02189 (10 uM) inhibits ERK5 phosphorylation, and reduces myocyte enhancer factor 2 (MEF2) transcriptional activity in neonatal rat cardiomyocytes (NRCMs) stimulated by isoproterenol. category Inhibitors(c1514) cas_num 1094614-85-3 Basic Info-
Product Name:
BIX 02189
Other Name:BIX 02189;3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide;(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide;3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide BIX 02189;BIX 02189, >=98%;(Z)-3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6;BIX-02189(Random Configuration)
CAS No.:1094614-85-3
Molecular Formula:C27H28N4O2
InChIKeys:HOMJAAIVTDVQJA-IZHYLOQSSA-N
Molecular Weight:440.53682
Exact Mass:440.221222
Categories:
Characteristics-
PSA:
64.7
XLogP3:3.5
Density:1.23
Flash Point:349.0±31.5 °C
Refractive Index:1.659
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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