MG-132
133407-82-6
99%
2026-08-10
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName MG-132 Cat No CEI-0222 Description MG-132 (ZLLLal) can potently inhibit proteasome with IC50 of 100 nM. CAS No 133407-82-6 Molecular Weight 475.62 Purity >99% Storage 2 years at -20 centigrade Targets proteasome Molecular Formula C26H41N3O5 Chemical Name benzyl (S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate Solubility DSMO Water Ethanol In vitro MG-132 displays >1000 times more activity than ZLLal in inhibiting the ZLLL-MCA-degrading activity of 20S proteasome with IC50 of 100 nM versus 110 uM. MG-132 also inhibits calpain with IC50 of 1.2 uM. MG-132 (10 uM) potently inhibits TNF-alpha-induced NF-kappaB activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells by inhibition of proteasome-mediated IkappaBalpha degradation. In vivo Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, beta-dystroglycan, alpha-bdystroglycan, and alpha-sarcoglycan in skeletal muscle fibers. category Inhibitors(c1514) cas_num 133407-82-6 Basic Info-
Product Name:
N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Other Name:L-Leucinamide,N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-;L-Leucinamide,N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(1-formyl-3-methylbutyl)-,(S)-;N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide;MG 132;Calpain inhibitor IV-2
CAS No.:133407-82-6
Molecular Formula:C26H41N3O5
InChIKeys:InChIKey=TZYWCYJVHRLUCT-VABKMULXSA-N
Molecular Weight:475.62
Exact Mass:475.62
UNII:RF1P63GW3K
DSSTox ID:DTXSID3042639
HScode:29242990
Categories:
Characteristics-
PSA:
114
XLogP3:4.8
Appearance:White solid film
Density:1.073
Melting Point:80-84 °C (decomp)
Boiling Point:682.0±55.0 °C(Predicted)
Flash Point:366℃
Refractive Index:1.506
Water Solubility:soluble in ethanol, chloroform, methanol, water.methanol: 1 mg/mL
Storage Conditions:−20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product