SB 203580
152121-47-6
99%
2026-07-03
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName SB 203580 Cat No CEI-0165 Description SB 203580 can inhibit p38 MAPK with IC50 of 300 nM. Alias SB-203580, SB203580 CAS No 152121-47-6 Molecular Weight 377.43 Purity >99% Storage 2 years at -20centigrade Powder Synonyms SB-203580, SB203580 Targets p38 MAPK Molecular Formula C21H16FN3OS Chemical Name 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine Solubility DMSO 76 mg/mL, Water In vitro SB 203580 is a specific inhibitor of a MAP kinase, which can inhibit reactivating kinase (RK) with IC50 of 0.6 uM. SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of heat shock protein (HSP) 27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo. category Inhibitors(c1514) cas_num 152121-47-6 Basic Info-
Product Name:
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Other Name:Pyridine,4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-;Pyridine,4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]-;4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine;SB 203580;PB 203580;RWJ 64809;BIRB 203580;4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine;224047-03-4
CAS No.:152121-47-6
Molecular Formula:C21H16FN3OS
InChIKeys:InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N
Molecular Weight:377.43
Exact Mass:377.43
DSSTox ID:DTXSID2040577
HScode:2818200000
Categories:
Characteristics-
PSA:
77.8
XLogP3:3.2
Appearance:white to off-white solid
Density:1.4±0.1 g/cm3
Melting Point:144-146
Boiling Point:615.6ºC at 760 mmHg
Flash Point:326.1±31.5 °C
Refractive Index:1.715
Water Solubility:DMSO: 50 mg/mL
Storage Conditions:−20°C
Vapor Pressure:2E-14mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Serious eye damage, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H318 Causes serious eye damage
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product