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PD 98059

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CAS No.:

167869-21-8

Content:

99%

Price valid (until):

2026-07-30

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
Seller Information

Description

ProductName	PD 98059
Cat No	CEI-0167
Description	PD 98059 can inhibit MEK1 and MEK2 with IC50 of 4 uM and 50 uM.
CAS No	167869-21-8
Molecular Weight	267.28
Purity	>99%
Storage	2 years at -20centigrade Powder
Targets	MEK1, MEK2
Molecular Formula	C16H13NO3
Chemical Name	2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one
Solubility	DMSO 19 mg/mL Water
In vitro	PD-98059 can inhibit MEK1 and MEK2 with IC50 of 4 uM and 50 uM. PD98059 does not change either the stabilization or DNA binding ability of HIF-1alpha but it inhibits the trans-activation ability of HIF-1alpha, thereby it reduces the hypoxia-induced transcription.
In vivo	(1) In human luteinized granulosa cells Inhibition of mitogen-activated protein (MAP) kinase kinase (MEK) with PD98059 in human luteinized granulosa cells will block epidermal growth (EGF)-stimulated MAP kinase activity and induce apoptosis. (2) In acute myeloid leukemia (AML) PD98059, an inhibitor of MAPKinase kinase (MEK) which activates MAPKinase, inhibited this transient ERK phosphorylation, but was unable to block maturation as measured by acquisition of CD15 in acute myeloid leukemia (AML). (3)Axonal growth PD98059 ([2-(2amino-3-methoxyphenyl)-oxanaphthalen-4-one]) blocks mitogen activated protein kinase and leave spontaneous axonal outgrowth unaffected with 50 uM by inhibiting nerve growth factor stimulated axon growth because nerve growth factor stimulated axonal outgrowth in vitro from adult mouse dorsal root ganglia utilizes the mitogen activated protein kinase pathway.
category	Inhibitors(c1514)
cas_num	167869-21-8

Basic Info

Product Name:

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Other Name:

4H-1-Benzopyran-4-one,2-(2-amino-3-methoxyphenyl)-;2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one;PD 98059;NSC 679828;PD 098059;2-(2′-amino-3′-methoxyphenyl)oxanaphthalen-4-one;2-(2-Amino-3-methoxyphenyl)chromen-4-one;2-(2-Amino-3-methoxyphenyl)-4H-chromen-4-one;868169-70-4

CAS No.:

167869-21-8

Molecular Formula:

C16H13NO3

InChIKeys:

InChIKey=QFWCYNPOPKQOKV-UHFFFAOYSA-N

Molecular Weight:

267.28

Exact Mass:

267.28

UNII:

SJE1IO5E3I

NSC Number:

679828

DSSTox ID:

DTXSID40168416

HScode:

29322090

Categories:

Inhibitors

Characteristics

PSA:

61.6

XLogP3:

2.9

Appearance:

yellow solid

Density:

1.300±0.06 g/cm3(Predicted)

Melting Point:

164～165℃

Boiling Point:

453.1±45.0 °C(Predicted)

Flash Point:

221.9±25.0 °C

Refractive Index:

1.652

Water Solubility:

ethanol: 0.6 mg/mL

Storage Conditions:

−20°C

Vapor Pressure:

2.12E-08mmHg at 25°C

See More 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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Product Name	Grade / Content	Price	Supplier Name	Details
PD 98059	/99.00		HANGZHOU LEAP CHEM CO., LTD.	Inquiry