TW-37
877877-35-5
99%
2026-07-21
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName TW-37 Cat No CEI-0181 Description As a new inhibitor,TW-37 can recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 uM, 1.11 uM and 0.26 uM. CAS No 877877-35-5 Molecular Weight 573.7 Purity >99% Storage 2 years at -20 centigrade Targets Bcl-2, Bcl-xL, Mcl-1 Molecular Formula C33H35NO6S Chemical Name 5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide Solubility DSMO 115 mg/mL Water In vitro As a potent inhibitor of Bcl-2, TW-37 can inhibit recombinant Bcl-2, Bcl-X(L), and Mcl-1 with Ki of 290 nM,110 nM and 260 nM. And TW-37 shows selectivity for Bcl-X(L). For cell lines, TW-37 showed significant antiproliferative effect to WSU-DLCL(2) lymphoma cell line and primary cells. TW-37 disrupted heterodimer formation between Bax and antiapoptotic proteins including Mcl-1, Bcl-2, and Bcl-X(L). TW-37 inhibited cell growth in a dose- and time-dependent manner. This was accompanied by increased apoptosis and concomitant attenuation of NF-kappaB, and downregulation of NF-kappaB downstream genes such as MMP-9 and VEGF, resulting in the inhibition of pancreatic cancer cell migration, invasion and angiogenesis in vitro. And TW-37 can cause apoptotic death. In vivo In Colo-357 human PC xenografts in SCID mice, TW-37 treatment signi?cantly inhibited tumor growth. TW-37 could affect the function of NF-kappaB in vivo, and the expression of VEGF, MMP-9, COX-2, Cyclin D1 and Survivin was also downregulated in TW-37-treated animals. category Inhibitors(c1514) cas_num 877877-35-5 Basic Info-
Product Name:
TW-37
Other Name:TW-37;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide;N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide;N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide;5-(2-isopropylbenzyl)-N-(4-(2-tert-butylphenylsulfonyl)phenyl)-2,3,4-trihydroxybenzamide;N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamideTW-37;Bcl-2 Inhibitor N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
CAS No.:877877-35-5
Molecular Formula:33H35NO6S
InChIKeys:PQAPVTKIEGUPRN-UHFFFAOYSA-N
Molecular Weight:573.6991
Exact Mass:573.218506
EC Number:-0
UNII:FQ8NY4LUO5
DSSTox ID:DTXSID10466395
Categories:
Characteristics-
PSA:
132
XLogP3:7.8
Density:1.3±0.1 g/cm3
Boiling Point:723.722°C at 760 mmHg
Flash Point:391.5±32.9 °C
Refractive Index:1.631
Storage Conditions:Store at -20°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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