Cyt387
3 Inquiries
1056634-68-4
99%
2026-07-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Cyt387 Cat No CEI-0196 Description Cyt387 can inhibit JAK1, JAK2 and JAK3 with IC50 of 11 nM, 18 nM and 155 nM. Alias CYT 11387 CAS No 1056634-68-4 Molecular Weight 414.46 Purity >99% Storage 2 years at -20centigrade Powder Synonyms CYT 11387 Targets JAK1, JAK2, JAK3 Molecular Formula C23H22N6O2 Chemical Name N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide Solubility DMSO 83 mg/mL Water In vitro As an inhibitor of Janus kinases, CYT387 can potently inhibit JAK1 and JAK2 with IC50 of 11 and 18 nM, but CYT387 is less potent towards JAK3 with IC50 of 155 nM. CYT387 is a ATP-competitive inhibitor. Researchers tested a list of kinases and conclude Kinase selectivity pro?le of CYT387. For some kinases, CYT387 showed potent inhibition and IC50 is less than 100 nM. They are JAK1, JAK2, CDK2/cyclin A, MAPK8(JNK1), ROCK2, and TBK1. (1) In vitro effects of CYT387 on JAK enzyme activity and on cell lines harboring JAK2, JAK3 or MPL activating mutations. According to this table, CYT387 showed potent inhibition to Ba/F3-MPLW515L, an IL-3 dependent murine pro B cell line with MPL constitutively activated. CYT387 also inhibit IL-3 dependent murine pro B cell lines harboring mutated JAK2 alleles and mutated JAK3 allele, and showed more potent inhibition to cell lines harboring mutated JAK3 alleles. (2) CYT387 inhibits phosphorylation of STAT-5 and STAT-3 in human erythroleukemia (HEL) cells. (3) CYT387 inhibits in vitro erythroid colony formation in polycythemia vera patients: exogenous erythropoietin attenuates this effect. (4) CYT387 caused growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines at the concentration between 0.5 and 1.5muM, while nonhematopoietic cell lines were unaffected. (5) CYT387 was able to prevent IL-6-induced phosphorylation of STAT3 and greatly decrease IL-6- and insulin-like growth factor-1-induced phosphorylation of AKT and extracellular signal-regulated kinase in human myeloma cell lines (HMCL). CYT387 inhibited MM proliferation in a time- and dose-dependent manner in HMCL, and this was not abrogated by the addition of exogenous IL-6. Cell cycling was inhibited with a G(2)/M accumulation of cells, and apoptosis was induced by CYT387 in all HMCL tested. category Inhibitors(c1514) cas_num 1056634-68-4 Basic Info-
Product Name:
Momelotinib
Other Name:Benzamide,N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-;N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide;CYT 387;Momelotinib;CYT 11387;CYT-0387;GS 0387;N-(Cyanomethyl)-4-[2-(4-morpholinoanilino)pyrimidin-4-yl]benzamide;CYT 387 mesylate;1160597-06-7
CAS No.:1056634-68-4
Molecular Formula:C23H22N6O2
InChIKeys:InChIKey=ZVHNDZWQTBEVRY-UHFFFAOYSA-N
Molecular Weight:414.45978
Exact Mass:414.46
UNII:6O01GMS00P
NCI Thesaurus Code:C88311
HScode:2934999090
Categories:
Characteristics-
PSA:
103
XLogP3:2.6
Appearance:Solid
Density:1.292
Refractive Index:1.646
Storage Conditions:at -20ºC 2 years
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Momelotinib
1 KG May 13, 2025
Pakistan
Momelotinib
1 KG May 12, 2025 
United States
CYT387/1056634-68-4/with high purity 99%
5 G Feb 15, 2025 Post an enquiry for this product