NVP-BSK805
1092499-93-8
99%
2026-07-05
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName NVP-BSK805 Cat No CEI-0200 Description NVP-BSK805 CAS No 1092499-93-8(freebase) Molecular Weight 563.47 Purity >99% Storage 2 years at -20 centigrade Targets JAK2 Molecular Formula C27H28F2N6O.2HCl Solubility No In vitro NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death. cas_num 1092499-93-8 category Inhibitors(c1514) Basic Info-
Product Name:
NVP-BSK805
Other Name:NVP-BSK805;NVP-BSK805 dihydrochloride;8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline;NVP-BSK805 2HCl;BSK 805;BSK805;BSK-805;8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline
CAS No.:1092499-93-8
Molecular Formula:C27H28F2N6O
InChIKeys:IBPVXAOOVUAOKJ-UHFFFAOYSA-N
Molecular Weight:490.5476264
Exact Mass:490.22926586
DSSTox ID:DTXSID20720930
Categories:
Characteristics-
PSA:
68.10000
XLogP3:4.46190
Density:1.4
Melting Point:137℃
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product