WZ3146
1214265-56-1
99%
2026-07-19
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName WZ3146 Cat No CEI-0026 Description WZ3146 CAS No 1214265-56-1 Molecular Weight 464.95 Purity >99% Storage 2 years at -20 centigrade Targets EGFR(L858R) Molecular Formula C24H25ClN6O2 Solubility No In vitro As an irreversible inhibitor, WZ3146 can inhibit EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. WZ3146 is profiled against Ba/F3 cells transformed with TEL fusions of BMX, BLK, JAK2 and JAK3. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR than WZ3146. category Inhibitors(c1514) cas_num 1214265-56-1 Basic Info-
Product Name:
WZ3146
Other Name:WZ3416;N-(3-(5-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamid;WZ3146;N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS No.:1214265-56-1
Molecular Formula:C24H25ClN6O2
InChIKeys:APHGZZPEOCCYNO-UHFFFAOYSA-N
Molecular Weight:464.96
Exact Mass:464.173
EC Number:-0
DSSTox ID:DTXSID10659649
Categories:
Characteristics-
PSA:
82.6
XLogP3:4.3
Density:1.318
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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