MLN2238
1072833-77-2
99%
2026-08-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName MLN2238 Cat No CEI-0223 Description MLN2238 shows inhibition to 20S proteasome with IC50 of 3.4 nM. CAS No 1072833-77-2 Molecular Weight 361.03 Purity >99% Storage 2 years at -20 centigrade Targets 20S proteasome Molecular Formula C14H19BCl2N2O4 Chemical Name (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Solubility DSMO 72 mg/mL Water In vitro MLN2238 is an N-capped dipeptidyl leucine boronic acid and it can inhibitthe chymotrypsin-like proteolytic (beta5) site of the 20S proteasome with an IC 50 value of 3.4 nmol/L and Ki of 0.93 nM. MLN2238 is similar to MLN9708. Actually, MLN2238 is the biologically active form of MLN9708, and MLN9708 immediately hydrolyzed to MLN2238 on exposure to aqueous solutions or plasma. As a potent inhibitor of the proteasome, MLN2238 lead to stabilization and accumulation of ubiquitinated proteins, resulting in cell cycle disruption, activation of apoptotic pathways, and active cell death. In vivo MLN2238 shows antitumor activity in the CWR22 xenograft model MLN2238 dosed at 14 mg/kg twice weekly and showed similar antitumor activity (T/C = 0.36) with bortezomib dosed at 0.8 mg/kg twice weekly . In WSU-DLCL2 xenograft model, MLN2238 dosed at 14 mg/kg twice weekly showed strong antitumor activity (T/C = 0.36), however, bortezomib dosed at 0.8 mg/kg twice weekly can not potently inhibit tumors.(T/C=0.79) category Inhibitors(c1514) cas_num 1072833-77-2 Basic Info-
Product Name:
Ixazomib
Other Name:Boronic acid,B-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-;B-[(1R)-1-[[2-[(2,5-Dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid;MLN 2238;Ixazomib;Ninlaro;(R)-1-(2-(2,5-Dichlorobenzamido)acetamido)-3-methylbutylboronicacid
CAS No.:1072833-77-2
Molecular Formula:C14H19BCl2N2O4
InChIKeys:InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N
Molecular Weight:361
Exact Mass:361.03
EC Number:1592732-453-0
UNII:71050168A2
NCI Thesaurus Code:C97940
ATC Code:L01XG03|L - Antineoplastic and immunomodulating agents
Categories:
Characteristics-
PSA:
98.7
XLogP3:2.46780
Appearance:Solid powder
Density:1.306
Refractive Index:1.546
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1A
Reproductive toxicity, Additional category for effects on or via lactation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
H362 May cause harm to breast-fed children
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product