MGCD-265
875337-44-3
99%
2026-08-07
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName MGCD-265 Cat No CEI-0037 Description As a multi-target inhibitor, MGCD-265 can inhibit Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM, and 7 nM. CAS No 875337-44-3 Molecular Weight 517.6 Purity >99% Storage 2 years at -20 centigrade Targets VEGFR1/VEGFR2/VEGFR3, Ron, Tie2, c-Met, Molecular Formula C26H20FN5O2S2 Solubility DSMO 104 mg/mL Water In vitro As a multi-target inhibitor, MGCD-265 can inhibit Met, VEGFR1, VEGFR2, VEGFR3, Ron, and Tie2 with IC50 of 1 nM, 3 nM, 3 nM, 4 nM, 2 nM, and 7 nM. MGCD-265 can inhibit Met phosphorylation in Met amplified cell and VEGFR2 phosphorylation with IC50 of 20 nM and 30 nM. MGCD-265 shows inhibition to cell lines including MKN45, MNNG-HOS, SNU-5, HCT116 and MDA-MB-231. By inhibiting c-Met phosphorylation, MGCD-265 can block the downstream signaling pathways of c-MET. In vivo In vivo, the combination of MGCD265 (10 mg/kg) and erlotinib (50 mg/kg) can result in tumor regression in a grastic tumor xenograft model. Combinatoin of MGCD265 and erlotinib regulate genes involved in tumor cell proliferation and apoptosis. And the the combination of MGCD265 and erlotinib in the MKN45 deregulate the RNA level of gene involved in glycolysis. category Inhibitors(c1514) cas_num 875337-44-3 Basic Info-
Product Name:
N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide
Other Name:N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide;MGCD-265 (Synonyms MGCD265);MGCD-265;N-(3-fluoro-4-(2-(1-Methyl-1H-iMidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbaMothioyl)-2-phen;N-[[[3-fluoro-4-[[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy]phenyl]amino]thioxomethyl]-benzeneacetamide;N-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamideMGCD-265;MGCD-265 analog;N-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbAmothioyl)-
CAS No.:875337-44-3
Molecular Formula:C26H20FN5O2S2
InChIKeys:UFICVEHDQUKCEA-UHFFFAOYSA-N
Molecular Weight:517.5977032
Exact Mass:517.104248
UNII:93M6577H9D
DSSTox ID:DTXSID60647874
Categories:
Characteristics-
PSA:
141
XLogP3:4.9
Appearance:White to off-white solid
Density:1.4±0.1 g/cm3
Boiling Point:195.7ºC at 760 mmHg
Flash Point:72.1ºC
Refractive Index:1.707
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H312 Harmful in contact with skin
H332 Harmful if inhaled
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product