NVP-AEW541
475489-16-8
99%
2026-08-10
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName NVP-AEW541 Cat No CEI-0042 Description NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM. Alias AEW541 CAS No 475489-16-8 Molecular Weight 439.55 Purity >99% Storage 2 years at -20centigrade Powder Synonyms AEW541 Targets IGF-IR, InsR Molecular Formula C27H29N5O Chemical Name 7-((1s,3s)-3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-(benzyloxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Solubility DMSO 88 mg/mL Water In vitro As a pyrrolo[2,3-d]pyrimidine derivative small molecular weight kinase inhibitor, NVP-AEW541 can inhibit IGF-IR and InsR with IC50 of 86 nM and 2300 nM. In vivo In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. NVP-AEW541 induced a G1 cell cycle block in all cells tested, whereas apoptosis was observed only in those cells that show a high level of sensitivity. Oral administration of NVP-AEW541 (50 mg/kg twice daily) inhibited tumor growth of neuroblastoma xenografts in nude mice. category Inhibitors(c1514) cas_num 475489-16-8 Basic Info-
Product Name:
7-[cis-3-(1-Azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Other Name:7H-Pyrrolo[2,3-d]pyrimidin-4-amine,7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-;7-[cis-3-(1-Azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;[7-[cis-3-[(Azetidin-1-yl)methyl]cyclobutyl]-5-(3-benzyloxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amine
CAS No.:475489-16-8
Molecular Formula:C27H29N5O
InChIKeys:InChIKey=AECDBHGVIIRMOI-GRGXKFILNA-N
Molecular Weight:439.552
Exact Mass:439.55
EC Number:-0
Categories:
Characteristics-
PSA:
69.2
XLogP3:4.66
Density:1.3±0.1 g/cm3
Melting Point:145 °C
Boiling Point:669.0±55.0 °C at 760 mmHg
Flash Point:358.4±31.5 °C
Refractive Index:1.710
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product