PF-04217903
956905-27-4
99%
2026-07-12
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PF-04217903 Cat No CEI-0061 Description PF-04217903, with triazolopyrazine chemical structure, can potently inhibit c-Met with IC50 of 4.8 nM. CAS No 956905-27-4 Molecular Weight 372.38 Purity >99% Storage 2 years at -20 centigrade Targets c-Met Molecular Formula C19H16N8O Chemical Name 2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol Solubility DSMO 5 mg/mL Water In vitro PF-04217903, with triazolopyrazine chemical structure, can potently inhibit c-Met with IC50 of 4.8 nM. PF-04217903 is a high selective and ATP-competitive inhibitor, and PF-04217903 shows more than 1000-fold selective relative to 208 kinases. PF-04217903 shows inhibition to c-Met-driven processes such as cell growth (proliferation and survival), motility, invasion, and morphology in a variety of tumor cells. In vivo Complete inhibition of c-Met activity by PF-04217903 only led to partial tumor growth inhibition (38%-46%) in human xenograft models that express relatively high levels of c-Met. PF-04217903 can potently induce phospho-PDGFRbeta (platelet-derived growth factor receptor) levels in U87MG xenograft tumor. category Inhibitors(c1514) cas_num 956905-27-4 Basic Info-
Product Name:
PD04217903
Other Name:PD04217903;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-(4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-1H-pyrazol-1-yl)ethanol;2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol PF 04217903;PF 04217903 2-[4-[1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl]ethanol;2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-y l]-1H-pyrazol-1-yl}ethanol
CAS No.:956905-27-4
Molecular Formula:C19H16N8O
InChIKeys:PDMUGYOXRHVNMO-UHFFFAOYSA-N
Molecular Weight:372.39
Exact Mass:372.144714
UNII:CYJ9ATV1IJ
NCI Thesaurus Code:C78483
Categories:
Characteristics-
PSA:
107
XLogP3:0.7
Density:1.5±0.1 g/cm3
Boiling Point:718.1°C at 760 mmHg
Flash Point:388.1±32.9 °C
Refractive Index:1.807
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product