Ivacaftor(VX-770)
873054-44-5
99%
2026-06-29
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Ivacaftor(VX-770) Cat No CEI-0251 Description VX-770 is an orally bioavailable CFTR potentiator and VX-770 is in clinical development for the treatment of Cystic fibrosis. CAS No 873054-44-5 Molecular Weight 392.49 Purity >99% Storage 2 years at -20centigrade Powder Targets G551D-CFTR, F508del-CFTR Molecular Formula C24H28N2O3 Chemical Name N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide Solubility DMSO 79 mg/mL Water In vitro VX-770 is an orally bioavailable CFTR potentiator and VX-770 is in clinical development for the treatment of Cystic fibrosis. VX-770 bound directly to the CFTR protein, rather than associated kinases or phosphatases. VX-770 can cause CFTR channel opening through a non-conventional, ATP-independent mechanism. In recombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing mutation and the G551D gating mutation. VX-770 also increased Cl(-) secretion in cultured human CF bronchial epithelia (HBE) carrying the G551D gating mutation on one allele and the F508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in HBE isolated from individuals without CF. VX-770 reduces excessive Na(+) and fluid absorption to prevent dehydration of the apical surface and increased cilia beating in these epithelial cultures. category Bulk Drug Intermediates(c1112) cas_num 873054-44-5 Basic Info-
Product Name:
Ivacaftor
Other Name:3-Quinolinecarboxamide,N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-;N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;VX 770;Ivacaftor;Kalydeco;N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide;N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide;N-[2,4-Di(tert-butyl)-5-hydroxyphenyl]-4-oxo-1H,4H-quinoline-3-carboxamide;1174930-71-2
CAS No.:873054-44-5
Molecular Formula:C24H28N2O3
InChIKeys:InChIKey=PURKAOJPTOLRMP-UHFFFAOYSA-N
Molecular Weight:392.49100
Exact Mass:392.49
UNII:1Y740ILL1Z
DSSTox ID:DTXSID00236281
ATC Code:R07AX30|R07AX02|R07AX31|R07AX|R - Respiratory system
HScode:29333990
Categories:
Characteristics-
PSA:
85.68000
XLogP3:5.6
Appearance:Solid
Density:1.187 g/cm3
Melting Point:212-215
Boiling Point:550.4ºC at 760 mmHg
Flash Point:286.7ºC
Refractive Index:1.606
Water Solubility:H2O: <0.05 µg/mL
PKA:11.08, 1.5
Dissociation Constants:11.08, 1.5
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
