KU-60019
925701-49-1
99%
2026-08-10
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName KU-60019 Cat No CEI-0082 Description KU-60019 can inhibit ATM with IC50 of 6.3 nM. CAS No 925701-49-1 Molecular Weight 547.67 Purity >99% Storage 2 years at -20 centigrade Targets ATM Molecular Formula C30H33N3O5S Chemical Name 2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide Solubility DSMO 40 mg/mL Water In vitro KU-60019 is an improved more water-soluble inhibitor of the ATM kinase, while displaying similar target selectivity. KU-60019 displays 3- to 10-fold more potency than KU-55933 at blocking radiation-induced phosphorylation of key ATM protein targets such as p53, gamma-H2AX, and CHK2, in human glioma U87 and U1242 cells. Consistent with the inhibition of prosurvival AKT signaling, KU-60019 at 3 uM significantly inhibits migration and invasion of human glioma U87 cells by >70% and 60%. category Inhibitors(c1514) cas_num 925701-49-1 Basic Info-
Product Name:
KU-60019
Other Name:KU-60019;(2R,6S)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;KU-60019(2R,6S)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;KU-60019, 925701-49-1;2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide
CAS No.:925701-49-1
Molecular Formula:C30H33N3O5S
InChIKeys:SCELLOWTHJGVIC-BGYRXZFFSA-N
Molecular Weight:547.67
Exact Mass:547.214
UNII:IAN358A69K
DSSTox ID:DTXSID00580453
Categories:
Characteristics-
PSA:
106
XLogP3:3.5
Density:1.314
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product