Topotecan HCl
119413-54-6
99%
2026-07-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Topotecan HCl Cat No CEI-0301 Description Topotecan (Hycamtin, NSC 609699) can inhibit topoisomerase I with IC50 of around 2 nM- 13 nM. Alias Hycamtin, NSC 609699 CAS No 119413-54-6 Molecular Weight 457.91 Purity >99% Storage 2 years at -20 centigrade Synonyms Hycamtin, NSC 609699 Targets topoisomerase I Molecular Formula C23H23N3O5.HCl Solubility DSMO 92 mg/mL Water 92 mg/mL Ethanol In vitro Stronger drug activity of Topotecan is observed for DU-145 Luc and MCF-7 Luc cells. Topotecan causes cytotoxicity during the course of DNA replication by stabilizing the covalent complex between topoisomerase I and DNA and preventing the religation of enzyme-linked single-strand DNA break. In vivo Animals inoculate s.c. with DU-145 Luc cells and then treated with Topotecan demonstrates significant tumor growth and regression as measured with calipers and luminescent imaging. The correlation coefficient is 0.75 for the control untreated group and 0.93 for the Topotecan-treated group. Similarly, tumor progression and regression are measurable using luminescent imaging for untreated and Topotecan-treated mice inoculated i.p. with MCF-7 Luc cells. category Antineoplastic Agents(c1417) cas_num 119413-54-6 Basic Info-
Product Name:
Topotecan hydrochloride
Other Name:1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,hydrochloride (1:1),(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,monohydrochloride,(4S)-;SKF 104864A;NSC 609669;Topotecan hydrochloride;Hycamtin;SKFS 104864A;Nogitecan hydrochloride;Topotecan chlorohydrate;(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[l,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride;Xinze
CAS No.:119413-54-6
Molecular Formula:C23H23N3O5.ClH
InChIKeys:InChIKey=DGHHQBMTXTWTJV-BQAIUKQQSA-N
Molecular Weight:457.91
Exact Mass:421.163757
EC Number:1308068-626-2
UNII:956S425ZCY
NSC Number:759263|609699
DSSTox ID:DTXSID1045952
NCI Thesaurus Code:C2828
ATC Code:L01CE01
HScode:29420000
Categories:
Characteristics-
PSA:
103
XLogP3:2.64880
Appearance:White Crystalline Solid
Density:1.5±0.1 g/cm3
Melting Point:215 °C (decomp)
Boiling Point:782.9ºC at 760mmHg
Flash Point:427.3±32.9 °C
Refractive Index:1.734
Storage Conditions:Refrigerator
Vapor Pressure:8.13E-26mmHg at 25°C
Collision Cross Section:211.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H340 May cause genetic defects
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product