Jervine
469-59-0
97%
2026-07-13
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Jervine Cat No CEI-0663 Description Cell-permeable. Structurally similar to cyclopamine. Inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Tomatidine is a useful negative control. Appearance Yellow solid Product Overview A sonic hedgehog (Shh) pathway inhibitor CAS No 469-59-0 Molecular Weight 442.94 Purity >97% by HPLC Storage -20 centigrade Targets SHH Molecular Formula C27H39NO3 Chemical Name 2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one Solubility DMSO (10 mM) Shipping Conditions Gel pack category Bulk Drug Intermediates(c1112) cas_num 469-59-0 Basic Info-
Product Name:
Jervine
Other Name:Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-,(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-;Jervine;Veratraman-11-one,17,23-epoxy-3-hydroxy-,(3β,23β)-;(2′R,3S,3′R,3′aS,6′S,6aS,6bS,7′aR,11aS,11bR)-2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-Hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one;Jervin;Spiro[9H-benzo[a]fluorene-9,2′(3′H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3′a,4,4′,5′,6,6′,6a,6b,7,7′,7′a,8,11a,11b-hexadecahydro-3-hydroxy-3′,6′,10,11b-tetramethyl-,[3S-(3α,6aα,6bβ,9α(3′S*,3′aR*,6′R*,7′aS*),11aβ,11bα)]-;NSC 23898;NSC 7520;30937-13-4
CAS No.:469-59-0
Molecular Formula:C27H39NO3
InChIKeys:InChIKey=CLEXYFLHGFJONT-DNMILWOZSA-N
Molecular Weight:425.613
Exact Mass:425.60
EC Number:207-417-9
UNII:19V3ECX465
NSC Number:23898|7520
Color/Form:NEEDLES FROM METHANOL + WATER
HScode:29349990
Categories:
Characteristics-
PSA:
58.6
XLogP3:2.9
Density:1.2±0.1 g/cm3
Melting Point:243.5-244.5 °C
Boiling Point:592°C at 760 mmHg
Flash Point:311.8±30.1 °C
Refractive Index:1.591
Water Solubility:SOL IN ALCOHOL, ACETONE, CHLOROFORM
Storage Conditions:-20ºC
Vapor Pressure:1.75E-16mmHg at 25°C
Toxicity:LD50 i.v. in mice: 9.3 mg/kg (Krayer); LD50 s.c. in male mice: 29 mg/kg (Tanaka)
Specific rotation:SPECIFIC OPTICAL ROTATION (ETHANOL): -150 DEG @ 20 °C/D; -167.6 DEG @ 20 °C/D (CHLOROFORM); MAX ABSORPTION: 250, 360 NM (E= 15,000, 60)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product