ON-01910
1225497-78-8
99%
2026-08-31
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName ON-01910 Cat No CEI-0303 Description ON 01910 can inhibit polo-like kinase 1 (Plk1) with IC50 of 9 nM. CAS No 1225497-78-8 Molecular Weight 473.47 Purity >99% Storage 2 years at -20 centigrade Targets PLK1 Molecular Formula C21H24NNaO8S Solubility DSMO Water Ethanol In vitro ON 01910 is a novel polo-like kinase 1 (Plk1) inhibitor and it inhibit PLK1 with IC50 of 9 nM. ON 01910 also shows cytotoxic activity against a variety of human tumor cell lines in vitro. ON 01910 can induce three major abnormalities in tumor cells, including abnormal cell division (irregular chromosomal segregation and cytokinesis), G2-M arrest and apoptosis, and decreased expression of Cdc25C in many tumor cell lines. In vivo In rats, single doses of 300 and 600 mg/m 2 of ON01910 produced no toxicity, and 1200 mg/m2 had only slight toxicity. There was no evidence of significant myelotoxicity, neuropathy, or cardiotoxicity in these toxicology studies. In xenograft mouse model systems, ON01910 inhibited the growth of a wide variety of human tumors, including liver, breast, and pancreatic cancers. category Amino Acids and Derivatives(c1517) cas_num 1225497-78-8 Basic Info-
Product Name:
ON-01910
Other Name:ON-01910;Estybon;N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium salt;ON 01910 sodium salt;Rigosertib (ON-01910);N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-glycine,sodium salt (1:1);N-[2-Methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine sodium saltRigosertib (ON-01910);sodium 2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate|||
CAS No.:1225497-78-8
Molecular Formula:C21H24NO8S.Na
InChIKeys:VLQLUZFVFXYXQE-USRGLUTNSA-M
Molecular Weight:473.472
Exact Mass:473.112030
EC Number:-0
Categories:
Characteristics-
PSA:
132
XLogP3:2.62230
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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