Clofarabine
123318-82-1
99%
2026-08-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Clofarabine Cat No CEI-0317 Description Clofarabine Alias Clolar, Evoltra CAS No 123318-82-1 Molecular Weight 303.68 Purity >99% Storage 2 years at -20 centigrade Synonyms Clolar, Evoltra Targets Ribonucleotide reductase Molecular Formula C10H11ClFN5O3 Solubility DMSO 61 mg/mL, Water In vitro Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis. It is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed. category Antineoplastic Agents(c1417) cas_num 123318-82-1 Basic Info-
Product Name:
Clofarabine
Other Name:9H-Purin-6-amine,2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-;2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine;2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine;Clofarabine;Clofarex;Clolar;Evoltra;Ivozall
CAS No.:123318-82-1
Molecular Formula:C10H11ClFN5O3
InChIKeys:InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N
Molecular Weight:303.68
Exact Mass:303.68
EC Number:2017-001-1
UNII:762RDY0Y2H
DSSTox ID:DTXSID5046437
NCI Thesaurus Code:C26638
ATC Code:L01BB06|L - Antineoplastic and immunomodulating agents
HScode:29349990
Categories:
Characteristics-
PSA:
119
XLogP3:0
Appearance:white Powder
Density:1.4804 (estimate)
Melting Point:225-227 °C @ Solvent: Ethanol, Water
Boiling Point:550.0±60.0 °C(Predicted)
Flash Point:286.4ºC
Refractive Index:1.843
Water Solubility:DMSO: >10mg/mL
Storage Conditions:Desiccate at +4°C
Vapor Pressure:3.19E-15mmHg at 25°C
Flammability characteristics:Combustible; Fire site decomposes toxic nitrogen oxides; Fluoride and chloride fumes
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product