Plumbagin
1 Inquiries
481-42-5
98%
Yes
2026-11-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Plumbagin Cat No CEI-0397 Description A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo. Alias 5-Hydroxy-2-methyl-1, 4-naphthalenedione Appearance Pale yellow solid Product Overview A potent histone acetyltransferase (HAT) inhibitor CAS No 481-42-5 Molecular Weight 384.27 Purity >98% by TLC Storage -20 centigrade Synonyms 5-Hydroxy-2-methyl-1,4-naphthalenedione Targets Akt, mTOR Molecular Formula C11H8O3 Chemical Name 5-Hydroxy-2-methyl-1,4-naphthalenedione Solubility DMSO (40 mg/ml) or EtOH (25 mg/ml) Shipping Conditions Gel pack category Organic Reagents(c2012) cas_num 481-42-5 ECHEMI Editorial ReferencePlumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities[1].
Plumbagin is a hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively. It has a role as a metabolite, an immunological adjuvant, an anticoagulant and an antineoplastic agent. It is a member of phenols and a hydroxy-1,4-naphthoquinone.Basic Info-
Product Name:
Plumbagin
Other Name:1,4-Naphthalenedione,5-hydroxy-2-methyl-;Plumbagin;1,4-Naphthoquinone,5-hydroxy-2-methyl-;5-Hydroxy-2-methyl-1,4-naphthalenedione;5-Hydroxy-2-methyl-1,4-naphthoquinone;2-Methyl-5-hydroxy-1,4-naphthoquinone;Plumbagine;Plumbagone;2-Methyljuglone;NSC 236613;NSC 688284;2-Methyl-5-hydroxy-1,4-naphthalenedione
CAS No.:481-42-5
Molecular Formula:C11H8O3
InChIKeys:InChIKey=VCMMXZQDRFWYSE-UHFFFAOYSA-N
Molecular Weight:188.18
Exact Mass:188.18
EC Number:207-569-6
UNII:YAS4TBQ4OQ
NSC Number:688284|236613
DSSTox ID:DTXSID8075413
HScode:2914690090
Categories:
Characteristics-
PSA:
54.4
XLogP3:2.3
Appearance:Orange Crystals or Crystalline Powder
Density:1.380 g/cm3
Melting Point:78.5 °C
Boiling Point:70-90 °C
Flash Point:200.2ºC
Refractive Index:1.63
Storage Conditions:−20°C
Vapor Pressure:1.92E-06mmHg at 25°C
Toxicity:LD50 i.p. in mice: ~0.015 g/kg (Debray)
Collision Cross Section:124.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin corrosion, Sub-category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H314 Causes severe skin burns and eye damage
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P316 Get emergency medical help immediately.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Nigeria
Plumbagin
10 G Jan 3, 2024 Post an enquiry for this product
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