ARN-509
2 Inquiries
956104-40-8
0.98%
2026-07-06
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName ARN-509 Cat No CEI-1217 Description ARN-509 is a selective and competitive inhibitor of androgen receptor with an IC50 value of 16 nM. Product Overview ARN-509, a synthetic biaryl thiohydantoin compound, is a competitive androgen receptor (AR) inhibitor and fully antagonistic to AR overexpression. The IC50 of ARN-509 is 16 nmol/L. AR, included in the steroid receptor superfamily, is important for prostate cell proliferation and male sexual differentiation. AR overexpression is a common and important feature of castration resistant prostate cancer (CRPC). ARN-509 (1 μmol/L) treatment for 48 hours resulted in increased DNA damage in LNCaP cells, LNCaP-AR cells and VCaP cells. In LNCaP cell line, treatment with ARN-509 (1 μmol/L) resulted in decreased cell survival. Treatment with ARN-509 (1 μmol/L) for 48 hours significantly decreased C-NHEJ-mediated recombination (>60%) in LNCaP cells that had been transfected with V(D)J recombination substrate along with RAG1 and RAG2 expression vectors. ARN-509 showed robust transcriptional and proliferative agonist activity in AR F876L-expressing cells, and promoted AR DNA binding in LNCaP/SRα F876L cells. Orally treated with ARN-509 (10 mg/kg/d) for 17 days, androgendriven luciferase reporter-gene activity in castrate male immunodeficient mice harboring LNCaP/AR-luc xenograft tumors (coexpressing exogenous AR and the AR-dependent reporter ARR2-Pb-luc), was consistently reduced. This indicated that ARN-509 inhibited AR in vivo. ARN-509 made tumors exhibit a decrease in proliferative index and an increase in apoptotic rate. CAS No 956104-40-8 Molecular Weight 477.43 Purity 0.98 Storage Store at -20°C Synonyms ARN 509; ARN509 Targets Androgen Receptor; GABAA receptor IC50 16 nM; 3 μM Molecular Formula C21H15F4N5O2S Chemical Name 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitors(c1514) cas_num 956104-40-8 Basic Info-
Product Name:
Apalutamide
Other Name:Benzamide,4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl-;4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide;4-[7-[6-Cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;ARN 509;A 52;Apalutamide;AR 509;Erleada;1361232-32-7
CAS No.:956104-40-8
Molecular Formula:C21H15F4N5O2S
InChIKeys:InChIKey=HJBWBFZLDZWPHF-UHFFFAOYSA-N
Molecular Weight:477.4347128
Exact Mass:477.43
EC Number:-0
Categories:
Characteristics-
PSA:
121
XLogP3:3
Density:1.6±0.1 g/cm3
Refractive Index:1.659
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
Apalutamide
100 KG Jan 3, 2024 
United States
ARN-509 99.5% white crystalline powder LUYUNJIA
1 KG Jun 11, 2023 Post an enquiry for this product