BMS 299897
290315-45-6
0.98%
2026-06-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BMS 299897 Cat No CEI-1249 Description BMS 299897 is a potent and orally active inhibitor of γ-secretase with IC50 value of 12 nM. Product Overview BMS-299897 is a selective inhibitor of γ-secretase with IC50 value of 12 nM. γ-secretase is an intergral membrane protein whose well-known substrate is amyloid precursor protein and involves in the process of cleaving single-pass transmembrane proteins at residues with the transmembrane domain. It has been revealed thatγ-secretase cleave APP in any of multiple sites and generate a 39 to 42 amino acids long peptide, among which Aβ40 is the most common isoform and Aβ42 is the most susceptible to conformational changes leading to amyloid fibrillogenesis. Many studies have shown that reduction of brain Aβ synthesis by gamma-secretase inhibitors is a promising approach for the Alzheimers disease treatment. BMS 299897 is a selective inhibitorγ-secretase. When tested HEKwt culture with BMS-299897, the expression of Aβ(1-40) in culture supernatant had a robust rise throughγ-secretase inhibition. In male Swiss mice model with intracerebroventricular (i. c. v.) injection of Aβ(25-35) which induced Alzheimers disease pathomimetic toxicity, administration of BMS-299897 markedly attenuated Aβ(1-42)-whose accumulation marginally contributed to the toxicity or long-term memory deficits-seeding and toxicity induced by Aβ(25-35) through inhibiting γ-secretase. When tested with Tg2576 mice, oral administration of BMS-299897 markedly reduced Abeta peptide concentrations by inhibitingγ-secretase. CAS No 290315-45-6 Molecular Weight 511.94 Purity 0.98 Storage Store at -20°C Targets γ-secretase IC50 12 nM Molecular Formula C24H21ClF3NO4S Chemical Name 4-[2-[(1R)-1-(N-(4-chlorophenyl)sulfonyl-2,5-difluoroanilino)ethyl]-5-fluorophenyl]butanoic acid Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 290315-45-6 Basic Info-
Product Name:
2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoicacid
Other Name:2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid;BMS 299897;γ-Secretase Inhibitor XXIV, BMS299897;BMS-299897 (BMS 299897;γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem;Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
CAS No.:290315-45-6
Molecular Formula:C24H21ClF3NO4S
InChIKeys:IZAOBRWCUGOKNH-OAHLLOKOSA-N
Molecular Weight:511.94
Exact Mass:511.0831915
UNII:QK855F579S
DSSTox ID:DTXSID50460039
Categories:
Characteristics-
PSA:
83.06000
XLogP3:7.20190
Appearance:White to off-white solid
Density:1.421±0.06 g/cm3
Boiling Point:620.0±65.0 °C(Predicted)
Flash Point:328.7ºC
PKA:4.71±0.10
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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