chroman 1
1273579-40-0
0.98%
2026-06-22
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName chroman 1 Cat No CEI-1281 Product Overview Chroman 1 is a highly potent ROCK-II inhibitor. ROCK is a member of the AGC kinase family of serine/threonine kinases that is comprised of two highly homologous isoforms, which are ROCK-I and ROCK-II. As one of the downstream effectors of RhoA, ROCK regulates stress fiber formation and actin cytoskeletal organization via phosphorylation of myosin light chain. Currently, there is plenty of interest in the inhibition of Rho kinase (ROCK) to treat various diseases. CAS No 1273579-40-0 Molecular Weight 436.5 Purity 0.98 Storage Store at -20°C Synonyms ROCK-II inhibitor Targets ROCK II Molecular Formula C24H28N4O4 Chemical Name (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro Chroman 1 was found to be a sub-nanomolar ROCK-II inhibitor with excellent to moderate selectivity over related kinases studied as a preliminary assessment, such as AKT1, protein kinase A (PKA), and the highly homologous Cdc42-binding kinase. In addition, Chroman 1 also showed good in-vitro activity in the functional cell-based myosin light chain bis-phosphorylation assay. In vivo Pharmacokinetic evaluation in rats showed that Chroman 1 had moderately improved oral bioavailability (27-35%) relative to its lead compounds, which were benzodioxane and chroman. In addition, Chroman 1 also displayed an unique intriguing pharmacokinetic profile, which was with high systemic exposure through oral delivery. category Specialty Chemicals(c26) cas_num 1273579-40-0 Basic Info-
Product Name:
N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide
Other Name:chroman 1;CHEMBL482336;1273579-40-0;SCHEMBL1989194;(3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide;BDBM50256322;N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-methoxychroman-3-carboxamide
CAS No.:1273579-40-0
Molecular Formula:C24H28N4O4
InChIKeys:ROFMCPHQNWGXGE-UHFFFAOYSA-N
Molecular Weight:436.5
Exact Mass:436.21105539
DSSTox ID:DTXSID70735357
Categories:
Characteristics -
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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