Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName Clemizole Cat No CEI-1284 Product Overview The NS4B protein is a key player in HCV replication. Disrupting NS4B function thus represents an attractive new anti-HCV strategy. Combining clemizole with other anti-HCV agents could increase the antiviral effect achieved with 1 active drug alone and decrease emergence of viral resistance. Clinical trial: The purpose of a study was to test the hypothesis that clemizole hydrochloride was safe and well tolerated when administered to subjects who were infected with hepatitis C virus and had not yet received treatment. This clinical study would also examine how the virus and body respond to clemizole hydrochloride. CAS No 442-52-4 Molecular Weight 325.84 Storage Store at -20°C Targets HCV Molecular Formula C19H20ClN3 Chemical Name 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro Although significant, clemizole's antiviral effect was moderate (50% effective concentration of 8 mM against a HCV genotype 2a clone). Clemizole's antiviral effect was highly synergistic with the HCV protease inhibitors VX950 and SCH503034, without toxicity. In contrast, clemizole combinations with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive. In vivo Clemizole had an unexpectedly short plasma half-life; it was very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice. category Specialty Chemicals(c26) cas_num 442-52-4 Basic Info-
Product Name:
Clemizole
Other Name:1H-Benzimidazole,1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-;Benzimidazole,1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-;Pyrrolidine,1-[(1-p-chlorobenzyl-2-benzimidazolyl)methyl]-;1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole;1-p-Chlorobenzyl-2-pyrrolidino-methylbenzimidazole;1-p-Chlorobenzyl-2-(1-pyrrolidinylmethyl)benzimidazole;1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole;Histacur;Histakool;Clemizole;Lergopenin;Depocural;NSC 46261
CAS No.:442-52-4
Molecular Formula:C19H20ClN3
InChIKeys:InChIKey=CJXAEXPPLWQRFR-UHFFFAOYSA-N
Molecular Weight:325.84
Exact Mass:325.84
EC Number:207-133-5
UNII:T97CB3796L
NSC Number:46261
DSSTox ID:DTXSID0046939
HScode:2933990090
Categories:
Characteristics-
PSA:
21.1
XLogP3:5.10
Density:1.3±0.1 g/cm3
Melting Point:167 °C
Boiling Point:506.1±40.0 °C at 760 mmHg
Flash Point:259.9±27.3 °C
Refractive Index:1.656
Vapor Pressure:2.29E-10mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product