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Perindopril Erbumine

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CAS No.:

131740-09-5

Content:

99%

Price valid (until):

2026-07-13

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Description

ProductName	Perindopril Erbumine
Cat No	CEI-0345
Description	Perindopril Erbumine
Alias	Aceon, Perindopril, Coversyl
CAS No	131740-09-5
Molecular Weight	441.6
Purity	>99%
Storage	2 years at -20centigrade Powder
Synonyms	Aceon, Perindopril, Coversyl
Targets	ACE
Molecular Formula	C21H20ClNO5.HCl
Chemical Name	2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride
Solubility	DMSO 88 mg/mL, Water
In vitro	Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of the angiotensin-converting enzyme (ACE) with bradykiningiotensin I selectivity ratio of 1.44. Perindopril Erbumine inhibits the angiotensin- and Abeta42-to-Abeta40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 uM, and 0.01-0.03 uM, respectively. Perindopril Erbumine (~2 uM) displays no significant cytotoxicity towards SCC-VII and KB cells, but can significantly reduce the production of angiotensin II and the transcription of VEGF in KB cells in a concentration-dependent manner.
category	Inhibitors(c1514)
cas_num	131740-09-5

Basic Info

Product Name:

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1)

Other Name:

4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-,hydrochloride (1:1);4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-,hydrochloride,cis-(-)-;4H-1-Benzopyran-4-one,2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-,hydrochloride;NSC 649890;HL 275 hydrochloride;Alvocidib hydrochloride;MDL 107826A;L 868275 hydrochloride;HMR 1275 hydrochloride;L 86-8275 hydrochloride;2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;Flavopiridol hydrochloride

CAS No.:

131740-09-5

Molecular Formula:

C21H20ClNO5.ClH

InChIKeys:

InChIKey=LGMSNQNWOCSPIK-LWHGMNCYSA-N

Molecular Weight:

438.3

Exact Mass:

437.079681

EC Number:

1592732-453-0

Categories:

Inhibitors

Characteristics

PSA:

90.2

Appearance:

white to light brown

Melting Point:

169.5-170°C

Flash Point:

318.8ºC

Water Solubility:

H2O: ~2mg/mL

Storage Conditions:

2-8°C

Specific rotation:

24D -1.73 to -3.9°

See More 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, hydrochloride (1:1) Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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