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Collagen proline hydroxylase inhibitor
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Collagen proline hydroxylase inhibitor
Collagen proline hydroxylase inhibitor
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CAS No.:
223666-07-7
Price valid (until):
2026-07-01
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Description
ProductName Collagen proline hydroxylase inhibitor Cat No CEI-1290 Product Overview Collagen proline hydroxylase inhibitor is one member of the collagen proline hydroxylase inhibitor family, which are used as antifibroproliferative agents. Proline hydroxylase is a multiple function oxygenase catalyzing specific prolyl residues in the collagen peptide precursor. Proline hydroxylase has been known as one of the critical enzymes in the biosynthesis of collagen and its activity is enhanced in tissues of various pathological fibrosis. Thus, the specific inhibitor of proline hydroxylase could have clinical application in fibrotic diseases treatment. CAS No 223666-07-7 Molecular Weight 354.36 Storage Store at -20°C Targets Collagen proline hydroxylase Molecular Formula C18H18N4O4 Chemical Name N-ethyl-8-nitro-7-oxo-N-propyl-10H-1,10-phenanthroline-3-carboxamide Solubility DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro One of collagen proline hydroxylase inhibitors, P-1894B, was found to in vitro inhibit proline hydroxylase and had been proposed as a topical treatment for dermal fibrosis. P-1894B was observed to be with similar activities on one fibroblast line from a patient with infection and two fibroblast lines from normal human skin. 72-hour drug exposure on growing cells showed both time-and dose-dependent inhibition of proliferation. A similar result was also observed in the epithelial cell line NCTC 2544. In vivo So far, collagen proline hydroxylase inhibitor has not been applied to animal in vivo study. category Specialty Chemicals(c26) cas_num 223666-07-7 Basic Info-
Product Name:
Collagen proline hydroxylase inhibitor
CAS No.:223666-07-7
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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