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4-[[4-(4-chlorophenoxy)phenyl]sulfonylmethyl]-N-hydroxyoxane-4-carboxamide
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CTS-1027
CTS-1027
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CAS No.:
193022-04-7
Content:
0.98%
Price valid (until):
2026-08-08
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CTS-1027 Cat No CEI-1296 Description CTS-1027 is an orally bioavailable and small-molecule inhibitor ofmatrix metalloproteinases (MMPs) with IC50 values of0.4 nM, 0.6 nM and 800 nM for MMP-2, MMP-13 and MMP-1, respectively. Product Overview CTS-1027 is a selective inhibitor of MMP with IC50 value of 0.4 nM for MMP 2 and 0.6 nM for MMP13.MMPs (matrix metalloproteinase) are zinc-dependent endopeptidases and play an important role in degrading all kinds of extracellular matrix proteins. It is well known that MMPs involve in the cleavage of cell surface receptors, the release of apoptotic ligands, and inactivation chemokine/cytokine. And MMPs also play a pivotal role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defense. In C57/BL6 mice model suffered bile duct ligation (BDL) for 14 days, gavage CTS-1027 reduced apoptosis of hepatocyte and bile infarcts which was a histologic indicator of liver injury at the same time activated stellate cells and reduced hepatic fibrogenesis. CAS No 193022-04-7 Molecular Weight 425.88 Purity 0.98 Storage Store at -20°C Synonyms RS 130830; Ro 1130830; CTS1027; CTS 1027; RS130830; Ro1130830; RS-130830; Ro-1130830 Targets MMPs IC50 0.4 nM; 0.6 nM; 800 nM Molecular Formula C19H20ClNO6S Chemical Name 4-[[4-(4-chlorophenoxy)phenyl]sulfonylmethyl]-N-hydroxyoxane-4-carboxamide Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Amides(c1311) cas_num 193022-04-7 Basic Info-
Product Name:
4-[[4-(4-chlorophenoxy)phenyl]sulfonylmethyl]-N-hydroxyoxane-4-carboxamide
Other Name:RS1; CTS-1027; 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE;
CAS No.:193022-04-7
Molecular Formula:C19H20ClNO6S
InChIKeys:ROSNVSQTEGHUKU-UHFFFAOYSA-N
Molecular Weight:425.88300
Exact Mass:425.0699862
UNII:2QD3F58224
DSSTox ID:DTXSID90172907
Categories:
Characteristics-
PSA:
113.80000
XLogP3:5.12930
Density:1.388g/cm3
Refractive Index:1.595
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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