GW441756
504433-23-2
Yes
2026-11-16
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName GW441756 Cat No CEI-0904 Description GW441756 is a potent, selective inhibitor of TrkA with IC50 of 2 nM, with very little activity to c-Raf1 and CDK2. CAS No 504433-23-2 Molecular Weight 275.3 Storage 2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO. Targets TrkA IC50 2 nM Molecular Formula C17H13N3O Chemical Name 2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]- Solubility DMSO 25 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL In vitro GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX productionand apoptosis in TrkA-overexpressing cells. category Inhibitors(c1514) cas_num 504433-23-2 ECHEMI Editorial ReferenceGW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.IC50 Value: 2 nM [1]Target: TrkAin vitro: GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a duringBasic Info-
Product Name:
GW441756
Other Name:1,3-DIHYDRO-3-[(1-METHYL-1H-INDOL-3-YL)METHYLENE]-2H-PYRROLO[3,2-B]PYRIDIN-2-ONE;GW 441756;Gw;2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-;(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one
CAS No.:504433-23-2
Molecular Formula:C17H13N3O
Molecular Weight:275.30462
Exact Mass:275.105865
Categories:
Characteristics-
Density:
1.3±0.1 g/cm3
Boiling Point:567.985°C at 760 mmHg
Flash Point:297.3±30.1 °C
Refractive Index:1.708
Storage Conditions:Store at RT
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
