Fagomine
53185-12-9
0.98%
2026-07-20
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Fagomine Cat No CEI-1336 Description D-Fagomine is an iminosugar used for diabetes Product Overview Fagomine is a good inhibitor of various Glycosidases, including rat intestinal surcase and bovine α-Fucosidase with IC50 of 90μM and 140 μM, respectively. Fagomine has been shown to have some activity against mammalian gut R-glucosidase and β-galactosidase, Moreover, fagomine was also found to have a potent antihyperglycemic effect in streptozocin-induced diabetic mice and to potentiate markedly immunoreactive insulin release. Fagomine inhibitory activity was tested against different enzymes with IC50 of 90μM and 140 μM for rat intestinal surcase and bovine α-Fucosidase, respectively. Furthermore, the IC50 values for α-glucosidase in rice and yeast, along with rat intestinal maltase and isomaltase were also determined and the results were 320 880 820 and 460μM, respectively. The activities of rice R-glucosidase and rat digestive glycosidases were determined using the appropriate disaccharides as substrates at the optimum pH of each enzyme. The released D-glucose was determined colorimetrically using the glucose B-test. Other glycosidase activities were determined using an appropriate p-nitrophenyl glycoside as a substrate at the optimum pH of each enzyme. D-Fagomine lowered postprandial glycaemia in SD rats after the intake of sucrose and starch. D-Fagomine effectively regulated postprandial glycaemia in a dose-dependent manner, which led to a reduction in AUC at 120 min between 17 % and 43 % after the intake of 1 g sucrose/kg body weight. D-Fagomine effectively modulates the glucose level in blood in a dose-dependent manner after the ingestion of sucrose or starch, probably by delaying saccharide hydrolysis by brush-border glycosidases. CAS No 53185-12-9 Molecular Weight 147.18 Purity 0.98 Storage Store at -20°C Synonyms D-Fagomine Targets Glycosidases Molecular Formula C6H13NO3 Chemical Name (2R,3R,4R)-2-(hydroxymethyl)piperidine-3,4-diol Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 53185-12-9 Basic Info-
Product Name:
Fagomine
Other Name:3,4-Piperidinediol,2-(hydroxymethyl)-,(2R,3R,4R)-;3,4-Piperidinediol,2-(hydroxymethyl)-,[2R-(2α,3β,4α)]-;(2R,3R,4R)-2-(Hydroxymethyl)-3,4-piperidinediol;Fagomine;1,2,5-Trideoxy-1,5-imino-D-arabino-hexitol;D-Fagomine
CAS No.:53185-12-9
Molecular Formula:C6H13NO3
InChIKeys:InChIKey=YZNNBIPIQWYLDM-HSUXUTPPSA-N
Molecular Weight:147.17 g/mol
Exact Mass:147.17
UNII:1M10C1P4SM
DSSTox ID:DTXSID10201243
HScode:2933399090
Categories:
Characteristics-
PSA:
72.7 Ų
XLogP3:-1.60880
Melting Point:185 °C
Boiling Point:315.00to316.00°C.@760.00mmHg(est)
Water Solubility:1e+006 mg/L @ 25 °C (est)
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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